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• W100209535 startingPage "830" @default.
• W100209535 abstract "Abstract The microanatomy of the dot-shaped, close-contact sites called podosomes and the mechanism of their formation have been investigated in vitro in the malignant lymphocytes of B chronic lymphocytic leukemia (B-CLL). In this paper the authors demonstrate that in B-CLL podosomes: (1) vinculin, talin, and beta 2 integrin (CD18) rings surround an F- actin core; (2) the beta 1 integrin is localized within the F-actin core; (3) the beta 3 integrin is not present. This distribution and organization of adhesion-related molecules appears to be unique to B- CLL lymphocytes, since it has not been observed in normal B cells. B- CLL adhesion and podosome formation are inhibited by the synthetic peptide GRGDSP that contains the Arg-Gly-Asp (RGD) sequence." @default.
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• W100209535 date "1988-08-01" @default.
• W100209535 modified "2023-10-14" @default.
• W100209535 title "Vinculin, talin, and integrins are localized at specific adhesion sites of malignant B lymphocytes" @default.
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• W100209535 doi "https://doi.org/10.1182/blood.v72.2.830.830" @default.
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