FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W100221550> ?p ?o ?g. }

• W100221550 endingPage "3036" @default.
• W100221550 startingPage "3027" @default.
• W100221550 abstract "Abstract X-linked severe combined immunodeficiency (XSCID) is a life-threatening syndrome in which both cellular and humoral immunity are profoundly compromised. This disease results from mutations in theIL2RG gene, which encodes the common cytokine receptor γ chain, γc. Previously, we generated γc-deficient mice as a murine model of XSCID. We have now used lethally irradiated γc-deficient mice to evaluate a gene therapeutic approach for treatment of this disease. Transfer of the human γc gene to repopulating hematopoietic stem cells using an ecotropic retrovirus resulted in an increase in T cells, B cells, natural killer (NK) cells, and intestinal intraepithelial lymphocytes, as well as normalization of the CD4:CD8 T-cell ratio and of serum Ig levels. In addition, the restored cells could proliferate in response to interleukin-2 (IL-2). Thus, our results provide added support that gene therapy is a feasible therapeutic strategy for XSCID. Moreover, because we used a vector directing expression of human γc to correct a defect in γc-deficient mice, these data also indicate that human γc can cooperate with the distinctive cytokine receptor chains such as IL-2Rβ and IL-7R to mediate responses to murine cytokines in vivo." @default.
• W100221550 created "2016-06-24" @default.
• W100221550 creator A5012950291 @default.
• W100221550 creator A5038837090 @default.
• W100221550 creator A5045213613 @default.
• W100221550 creator A5046821514 @default.
• W100221550 creator A5063483109 @default.
• W100221550 creator A5082645346 @default.
• W100221550 creator A5090916329 @default.
• W100221550 creator A5091715108 @default.
• W100221550 date "1999-11-01" @default.
• W100221550 modified "2023-09-28" @default.
• W100221550 title "Restoration of Lymphoid Populations in a Murine Model of X-Linked Severe Combined Immunodeficiency by a Gene-Therapy Approach" @default.
• W100221550 cites W110839551 @default.
• W100221550 cites W1482176142 @default.
• W100221550 cites W1491681820 @default.
• W100221550 cites W1509163238 @default.
• W100221550 cites W1567604499 @default.
• W100221550 cites W1603378909 @default.
• W100221550 cites W1756978269 @default.
• W100221550 cites W1971500432 @default.
• W100221550 cites W1971731547 @default.
• W100221550 cites W1972044265 @default.
• W100221550 cites W1972254316 @default.
• W100221550 cites W1981150156 @default.
• W100221550 cites W2021820438 @default.
• W100221550 cites W2023177880 @default.
• W100221550 cites W2024292299 @default.
• W100221550 cites W2027878613 @default.
• W100221550 cites W2028091596 @default.
• W100221550 cites W2038705787 @default.
• W100221550 cites W2055483105 @default.
• W100221550 cites W2057142537 @default.
• W100221550 cites W2067194336 @default.
• W100221550 cites W2083685529 @default.
• W100221550 cites W2084228983 @default.
• W100221550 cites W2087852931 @default.
• W100221550 cites W2093804554 @default.
• W100221550 cites W2096661621 @default.
• W100221550 cites W2098873212 @default.
• W100221550 cites W2100938356 @default.
• W100221550 cites W2153011776 @default.
• W100221550 cites W2158270563 @default.
• W100221550 cites W2268875976 @default.
• W100221550 cites W2280192492 @default.
• W100221550 cites W2293072912 @default.
• W100221550 cites W2346539986 @default.
• W100221550 cites W2395212933 @default.
• W100221550 cites W25119911 @default.
• W100221550 cites W4235751459 @default.
• W100221550 cites W4255858411 @default.
• W100221550 doi "https://doi.org/10.1182/blood.v94.9.3027" @default.
• W100221550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10556186" @default.
• W100221550 hasPublicationYear "1999" @default.
• W100221550 type Work @default.
• W100221550 sameAs 100221550 @default.
• W100221550 citedByCount "73" @default.
• W100221550 countsByYear W1002215502012 @default.
• W100221550 countsByYear W1002215502013 @default.
• W100221550 countsByYear W1002215502014 @default.
• W100221550 countsByYear W1002215502017 @default.
• W100221550 countsByYear W1002215502018 @default.
• W100221550 countsByYear W1002215502019 @default.
• W100221550 crossrefType "journal-article" @default.
• W100221550 hasAuthorship W100221550A5012950291 @default.
• W100221550 hasAuthorship W100221550A5038837090 @default.
• W100221550 hasAuthorship W100221550A5045213613 @default.
• W100221550 hasAuthorship W100221550A5046821514 @default.
• W100221550 hasAuthorship W100221550A5063483109 @default.
• W100221550 hasAuthorship W100221550A5082645346 @default.
• W100221550 hasAuthorship W100221550A5090916329 @default.
• W100221550 hasAuthorship W100221550A5091715108 @default.
• W100221550 hasConcept C102230213 @default.
• W100221550 hasConcept C104317684 @default.
• W100221550 hasConcept C109159458 @default.
• W100221550 hasConcept C111599444 @default.
• W100221550 hasConcept C159047783 @default.
• W100221550 hasConcept C167672396 @default.
• W100221550 hasConcept C187316574 @default.
• W100221550 hasConcept C203014093 @default.
• W100221550 hasConcept C207001950 @default.
• W100221550 hasConcept C2777607303 @default.
• W100221550 hasConcept C2778690821 @default.
• W100221550 hasConcept C2779468541 @default.
• W100221550 hasConcept C28328180 @default.
• W100221550 hasConcept C502942594 @default.
• W100221550 hasConcept C54355233 @default.
• W100221550 hasConcept C74172505 @default.
• W100221550 hasConcept C86803240 @default.
• W100221550 hasConcept C8891405 @default.
• W100221550 hasConcept C95444343 @default.
• W100221550 hasConcept C98119934 @default.
• W100221550 hasConcept C98654944 @default.
• W100221550 hasConceptScore W100221550C102230213 @default.
• W100221550 hasConceptScore W100221550C104317684 @default.
• W100221550 hasConceptScore W100221550C109159458 @default.
• W100221550 hasConceptScore W100221550C111599444 @default.
• W100221550 hasConceptScore W100221550C159047783 @default.

• next