Matches in SemOpenAlex for { <https://semopenalex.org/work/W100257969> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- W100257969 abstract "This study was conducted mainly to determine the major flavonoid compounds and the composition of essential oils predominant in Clausena excavata, and also toexamine its antioxidant, antibacterial and anticancer activities. The dried yields of C. excavata’s leaf crude extracts were also determined and methanol was found to bethe best solvent for extracting soluble bioactive compounds from the leaves of C. excavata. Total phenolic contents were found abundantly in methanol crude extract of leaves. In the high performance liquid chromatography (HPLC) analysis, rutin and naringin were found predominant in the leaves of C. excavata, while in the gas chromatography-mass spectrometry (GC-MS) analysis, the major chemicalcomponents identified in the fruit oil were α-ocimene and terpinolene. Terpinolene was also being the main component and remarkably present in the leaf oil. Both ofthe fruit and leaf oils extracted with dichloromethane in the simultaneous distillation extraction (SDE) method were indicated in very low yield (less than 0.1%).Antioxidant activities of various crude extracts of Clausena excavata leaves were dependent on the amount of total phenolics present in the crude extracts. Inhibitionof lipid peroxidation and free radical scavenger potential of those crude extracts closely dependent on the particular substitution pattern of free hydroxyl groups on the flavonoid skeleton. Antioxidant activity of methanol crude leaf’s extract was found greater than α-tocopherol in the ferric thiocyanate (FTC) and thiobarbituric acid (TBA) methods as well. The increase in the concentration of methanol crude leaf extract from 200 to 1000 μg/ml had increased its antioxidant activity. However, methanol crude leaf’s extract exhibited weak scavenging activity towards 1,1- diphenyl-2-picrylhydrazyl (DPPH) free radical. As for the determination of antibacterial activity in both of the disc diffusion and microdilution methods, thegrowth of all tested gram-positive bacteria, especially Micrococcus luteus was found effectively affected by the methanol crude leaf extract. Almost all of the crudeextracts were active towards Micrococcus luteus. Fruit and leaf oil exhibited their effects on all tested gram-positive bacteria and certain gram-negative bacteria but those tested bacteria strains were just weakly inhibited. Antioxidant activity of flavonoids was associated with anticancer properties. In the MTT assay, however, fruit oil showed better cytotoxic activity than that in methanol crude leaf extract against MCF-7 cells. This implied that C. excavata fruit oil might be a good source for the breast cancer treatment due to the presence of possible active anticancer agents." @default.
- W100257969 created "2016-06-24" @default.
- W100257969 creator A5038194760 @default.
- W100257969 date "2004-01-01" @default.
- W100257969 modified "2023-09-27" @default.
- W100257969 title "Analysis of Flavonoids and Essential Oils from Clausena Excavata and Their Medicinal Properties" @default.
- W100257969 hasPublicationYear "2004" @default.
- W100257969 type Work @default.
- W100257969 sameAs 100257969 @default.
- W100257969 citedByCount "0" @default.
- W100257969 crossrefType "dissertation" @default.
- W100257969 hasAuthorship W100257969A5038194760 @default.
- W100257969 hasConcept C178790620 @default.
- W100257969 hasConcept C185592680 @default.
- W100257969 hasConcept C2775963812 @default.
- W100257969 hasConcept C2777335409 @default.
- W100257969 hasConcept C2778004101 @default.
- W100257969 hasConcept C2779054382 @default.
- W100257969 hasConcept C43617362 @default.
- W100257969 hasConceptScore W100257969C178790620 @default.
- W100257969 hasConceptScore W100257969C185592680 @default.
- W100257969 hasConceptScore W100257969C2775963812 @default.
- W100257969 hasConceptScore W100257969C2777335409 @default.
- W100257969 hasConceptScore W100257969C2778004101 @default.
- W100257969 hasConceptScore W100257969C2779054382 @default.
- W100257969 hasConceptScore W100257969C43617362 @default.
- W100257969 hasLocation W1002579691 @default.
- W100257969 hasOpenAccess W100257969 @default.
- W100257969 hasPrimaryLocation W1002579691 @default.
- W100257969 hasRelatedWork W1626589338 @default.
- W100257969 hasRelatedWork W1990715820 @default.
- W100257969 hasRelatedWork W2003359467 @default.
- W100257969 hasRelatedWork W2055175318 @default.
- W100257969 hasRelatedWork W2073190468 @default.
- W100257969 hasRelatedWork W2093577662 @default.
- W100257969 hasRelatedWork W2183849451 @default.
- W100257969 hasRelatedWork W2620743743 @default.
- W100257969 hasRelatedWork W2741915527 @default.
- W100257969 hasRelatedWork W2781527327 @default.
- W100257969 hasRelatedWork W2782542876 @default.
- W100257969 hasRelatedWork W2884887318 @default.
- W100257969 hasRelatedWork W2997329830 @default.
- W100257969 hasRelatedWork W3082985408 @default.
- W100257969 hasRelatedWork W3119627771 @default.
- W100257969 hasRelatedWork W3135458635 @default.
- W100257969 hasRelatedWork W3195992233 @default.
- W100257969 hasRelatedWork W44920161 @default.
- W100257969 hasRelatedWork W563841486 @default.
- W100257969 hasRelatedWork W88732571 @default.
- W100257969 isParatext "false" @default.
- W100257969 isRetracted "false" @default.
- W100257969 magId "100257969" @default.
- W100257969 workType "dissertation" @default.