Matches in SemOpenAlex for { <https://semopenalex.org/work/W100292237> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W100292237 abstract "Circadian clocks have evolved in all light sensitive organisms from cyanobacteria to mammals. These timing systems allow the organism to adjust their physiology and behavior to the geo-physical time. In mammals the circadian clocks exist in virtually all body cells, but the system function in a hierarchical manner in which the master pacemaker in the suprachiasmatic nucleus (SCN) sets the pace of the subsidiary peripheral oscillators. SCN is a small, approximately 10 000-20 000 cells, neuroendocrine gland in the hypothalamus. The SCN receives a direct photic input from the retina through the retino-hypothalamic tract and transmits this information to the oscillators in the periphery using neuronal and humoral signals. The molecular clock both in the SCN and in the peripheral oscillators is thought to consist of negative transcriptional and translational feedback loops. The PAS domain basic helix-loop-helix transcription factors BMAL1 and CLOCK bind to the promoters and transactivate two cryptochrome (cry) and two period (per) genes. Once CRY and PER proteins reach the threshold concentration they translocate into the nucleus and inhibit the activity of BMAL1-CLOCK heterodimer and repress their own genes. In addition, Bmal1 is rhythmically activated and repressed by orphan nuclear receptors RORs and REV-ERB? respectively in the interconnecting loop. Post-translational modifications such as phosphorylation, acetylation, sumoylation, and ubiquitination play an important role in fine-tuning the oscillator to measure 24 hour periodicity. The regulation of CRY protein stability and accumulation is particularly important for functional circadian oscillator. CRYs are ubiquitinated by the SCF-FBXL3 ubiquitin E3-ligase in timely regulated manner and subsequently degraded by the proteasome." @default.
- W100292237 created "2016-06-24" @default.
- W100292237 creator A5053043143 @default.
- W100292237 date "2009-01-01" @default.
- W100292237 modified "2023-09-27" @default.
- W100292237 title "CRY associated proteins modulate circadian transcription by regulating CRY stability" @default.
- W100292237 doi "https://doi.org/10.13097/archive-ouverte/unige:5154" @default.
- W100292237 hasPublicationYear "2009" @default.
- W100292237 type Work @default.
- W100292237 sameAs 100292237 @default.
- W100292237 citedByCount "0" @default.
- W100292237 crossrefType "dissertation" @default.
- W100292237 hasAuthorship W100292237A5053043143 @default.
- W100292237 hasConcept C104317684 @default.
- W100292237 hasConcept C121446783 @default.
- W100292237 hasConcept C144543706 @default.
- W100292237 hasConcept C169760540 @default.
- W100292237 hasConcept C171350616 @default.
- W100292237 hasConcept C25602115 @default.
- W100292237 hasConcept C2779317972 @default.
- W100292237 hasConcept C38606739 @default.
- W100292237 hasConcept C54355233 @default.
- W100292237 hasConcept C86339819 @default.
- W100292237 hasConcept C86803240 @default.
- W100292237 hasConcept C95444343 @default.
- W100292237 hasConceptScore W100292237C104317684 @default.
- W100292237 hasConceptScore W100292237C121446783 @default.
- W100292237 hasConceptScore W100292237C144543706 @default.
- W100292237 hasConceptScore W100292237C169760540 @default.
- W100292237 hasConceptScore W100292237C171350616 @default.
- W100292237 hasConceptScore W100292237C25602115 @default.
- W100292237 hasConceptScore W100292237C2779317972 @default.
- W100292237 hasConceptScore W100292237C38606739 @default.
- W100292237 hasConceptScore W100292237C54355233 @default.
- W100292237 hasConceptScore W100292237C86339819 @default.
- W100292237 hasConceptScore W100292237C86803240 @default.
- W100292237 hasConceptScore W100292237C95444343 @default.
- W100292237 hasLocation W1002922371 @default.
- W100292237 hasOpenAccess W100292237 @default.
- W100292237 hasPrimaryLocation W1002922371 @default.
- W100292237 hasRelatedWork W1997426777 @default.
- W100292237 hasRelatedWork W2013855904 @default.
- W100292237 hasRelatedWork W2031329949 @default.
- W100292237 hasRelatedWork W2061769555 @default.
- W100292237 hasRelatedWork W2072973584 @default.
- W100292237 hasRelatedWork W2097883984 @default.
- W100292237 hasRelatedWork W2128482458 @default.
- W100292237 hasRelatedWork W2131963452 @default.
- W100292237 hasRelatedWork W2140241157 @default.
- W100292237 hasRelatedWork W2233717703 @default.
- W100292237 hasRelatedWork W2407795681 @default.
- W100292237 hasRelatedWork W2418373458 @default.
- W100292237 hasRelatedWork W2781881684 @default.
- W100292237 hasRelatedWork W2889092943 @default.
- W100292237 hasRelatedWork W2969220148 @default.
- W100292237 hasRelatedWork W3006680225 @default.
- W100292237 hasRelatedWork W3092527891 @default.
- W100292237 hasRelatedWork W3093660756 @default.
- W100292237 hasRelatedWork W3117183245 @default.
- W100292237 hasRelatedWork W66370885 @default.
- W100292237 isParatext "false" @default.
- W100292237 isRetracted "false" @default.
- W100292237 magId "100292237" @default.
- W100292237 workType "dissertation" @default.