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- W100295083 abstract "There is increasing evidence that micronutrient deficiencies, such as zinc, may damage DNA. In the current study, we examined the effects of zinc status on DNA damage and transcription factors in both human and rat. In the human study, healthy adult males were first given a zinc adequate diet (11mg/d) for 13d to ensure normal baseline zinc. For the zinc depletion period, subjects were given a liquid diet (0.6mg/d) for 7d, and then given a low zinc diet (4mg/d) for an additional 35d. Finally, subjects were repleted with adequate zinc (11mg/d) diet for 28d, with supplemental zinc (20mg/d) given for the first 7d. At the end of each phase, blood cell DNA damage was assessed by comet assay. After zinc depletion, there was no significant change in DNA damage. However, after zinc repletion, there was a 40% decrease in DNA damage compared to baseline. To further examine mechanisms, we measured DNA damage and transcription factor function in zinc deficient rats. SD rats (n=12/group) were fed a zinc-adequate (50ppm), zinc-deficient (<0.05ppm) or pair-fed diet for 4wk. Similar to the human study; no change in DNA damage was seen with zinc deficiency. However, using transcription factor arrays, we found that p53, SP1, xenobiotic response element (XRE), c-Myb and C/EBP were up-regulated, while c-Myb binding protein and ETF were down-regulated in tissues. Microarray analysis also revealed differential gene expression changes with zinc deficiency. Together, these data suggest that zinc status may play an important role in the regulation of gene expression and DNA integrity. This work supported by the NCBA (KHB) and USDA 2005-35200-15439 (EH)." @default.
- W100295083 created "2016-06-24" @default.
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- W100295083 date "2006-03-01" @default.
- W100295083 modified "2023-09-26" @default.
- W100295083 title "Alterations in zinc status affects DNA integrity and transcription factor binding in vivo" @default.
- W100295083 doi "https://doi.org/10.1096/fasebj.20.5.a996-b" @default.
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