FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1002958368> ?p ?o ?g. }

• W1002958368 endingPage "30" @default.
• W1002958368 startingPage "116" @default.
• W1002958368 abstract "Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease affecting 1-2% of the population over 60. Although diagnosed by its characteristic motor manifestations, PD may be preceded, and is frequently accompanied, by a wide range of psychiatric and cognitive symptoms. These symptoms are often more debilitating than its motor complications and it is nowadays appreciated that they can be an important cause of excess disability in PD, frequently necessitating hospitalization and institutionalization. Despite their frequent occurrence, most PD-related neuropsychiatric symptoms remain under-recognized and undertreated in clinical practice and their diagnosis is challenging because of the overlap of the somatic features of the psychiatric disorders and the motor symptoms of PD. Even when identified, there is a common perception that many of these symptoms are untreatable. Their recognition is essential not only for ascertaining the functional status of patients but also for better appreciating the nature of the neurodegenerative process in PD. These symptoms may precede the onset of motor symptoms and can be used as screening tools allowing for very early disease identification and for trials of possible diseasemodifying interventions. The pathophysiology of neuropsychiatric symptoms in PD involves complex and multifactorial mechanisms, including disease-related and psychological factors. Alterations in neurotransmitters like dopamine, serotonin, acetylcholine, involving subcortical projections and synaptic and neuronal changes involving limbic and cortical structures combine to result in these nonmotor symptoms. Potentially earlier evaluation and treatment of comorbid psychiatric and cognitive disorders in PD could improve quality of life and patient productivity, reduce morbidity and caregiver burden, and minimize healthcare costs. Management strategies include adjustment of dopaminergic medication, use of psychotropic treatments and behavioral and psychological interventions. Dopaminergic medication may precipitate neuropsychiatric conditions, such as the dopamine dysregulation syndrome. The choice of psychotropic medication for the neuropsychiatric symptoms of PD is determined by a balance between potential benefit versus side effects, mostly in terms of worsening motor symptoms. Furthermore, treatments used in general psychiatry services may not be as effective in PD. This article provides an overview and focuses on the neuropsychiatric manifestations in PD including depression, anxiety, psychosis, apathy and fatigue, personality, sexual dysfunction, sleep disorders, cognitive impairment and dementia, impulse control disorders and related behaviours. The epidemiology, pathophysiology and risk factors, clinical presentation and management of the most common neuropsychiatric complications in PD are discussed." @default.
• W1002958368 created "2016-06-24" @default.
• W1002958368 creator A5025599420 @default.
• W1002958368 creator A5075368498 @default.
• W1002958368 date "2015-07-22" @default.
• W1002958368 modified "2023-10-18" @default.
• W1002958368 title "[Neuropsychiatric manifestations in Parkinson's disease]." @default.
• W1002958368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26197101" @default.
• W1002958368 hasPublicationYear "2015" @default.
• W1002958368 type Work @default.
• W1002958368 sameAs 1002958368 @default.
• W1002958368 citedByCount "9" @default.
• W1002958368 countsByYear W10029583682016 @default.
• W1002958368 countsByYear W10029583682017 @default.
• W1002958368 countsByYear W10029583682018 @default.
• W1002958368 countsByYear W10029583682019 @default.
• W1002958368 countsByYear W10029583682020 @default.
• W1002958368 countsByYear W10029583682022 @default.
• W1002958368 crossrefType "journal-article" @default.
• W1002958368 hasAuthorship W1002958368A5025599420 @default.
• W1002958368 hasAuthorship W1002958368A5075368498 @default.
• W1002958368 hasConcept C118552586 @default.
• W1002958368 hasConcept C126322002 @default.
• W1002958368 hasConcept C15744967 @default.
• W1002958368 hasConcept C159110408 @default.
• W1002958368 hasConcept C169760540 @default.
• W1002958368 hasConcept C169900460 @default.
• W1002958368 hasConcept C2779134260 @default.
• W1002958368 hasConcept C2779483572 @default.
• W1002958368 hasConcept C2779734285 @default.
• W1002958368 hasConcept C2779951463 @default.
• W1002958368 hasConcept C2908647359 @default.
• W1002958368 hasConcept C3018987647 @default.
• W1002958368 hasConcept C71924100 @default.
• W1002958368 hasConcept C99454951 @default.
• W1002958368 hasConceptScore W1002958368C118552586 @default.
• W1002958368 hasConceptScore W1002958368C126322002 @default.
• W1002958368 hasConceptScore W1002958368C15744967 @default.
• W1002958368 hasConceptScore W1002958368C159110408 @default.
• W1002958368 hasConceptScore W1002958368C169760540 @default.
• W1002958368 hasConceptScore W1002958368C169900460 @default.
• W1002958368 hasConceptScore W1002958368C2779134260 @default.
• W1002958368 hasConceptScore W1002958368C2779483572 @default.
• W1002958368 hasConceptScore W1002958368C2779734285 @default.
• W1002958368 hasConceptScore W1002958368C2779951463 @default.
• W1002958368 hasConceptScore W1002958368C2908647359 @default.
• W1002958368 hasConceptScore W1002958368C3018987647 @default.
• W1002958368 hasConceptScore W1002958368C71924100 @default.
• W1002958368 hasConceptScore W1002958368C99454951 @default.
• W1002958368 hasIssue "2" @default.
• W1002958368 hasLocation W10029583681 @default.
• W1002958368 hasOpenAccess W1002958368 @default.
• W1002958368 hasPrimaryLocation W10029583681 @default.
• W1002958368 hasRelatedWork W2061239682 @default.
• W1002958368 hasRelatedWork W2106304681 @default.
• W1002958368 hasRelatedWork W2110496054 @default.
• W1002958368 hasRelatedWork W2129250838 @default.
• W1002958368 hasRelatedWork W2143883805 @default.
• W1002958368 hasRelatedWork W2338128126 @default.
• W1002958368 hasRelatedWork W2660446955 @default.
• W1002958368 hasRelatedWork W2892061271 @default.
• W1002958368 hasRelatedWork W2995329450 @default.
• W1002958368 hasRelatedWork W3209291259 @default.
• W1002958368 hasVolume "26" @default.
• W1002958368 isParatext "false" @default.
• W1002958368 isRetracted "false" @default.
• W1002958368 magId "1002958368" @default.
• W1002958368 workType "article" @default.