Matches in SemOpenAlex for { <https://semopenalex.org/work/W1003272834> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1003272834 abstract "Introduction Increased ROS is associated with vascular pathology. Recent reports showed that whereas short-term (4 weeks) increase in NADPH oxidase-derived endothelium (EC)-specific ROS improved coronary endothelial function, long-term (16+ weeks) increase in ROS had adverse effects. Hypothesis We tested the hypothesis that short-term (4-8 weeks) ROS increase induces AMPK-FOXO1-mediated expression of SOD2 and thus exert protective effects on EC mitochondria; in contrast, long-term (16-20 weeks) ROS increase results in nitrotyration and inactivation of MnSOD, mitochondrial membrane potential loss, and mitophagy in EC. Results: Our binary (Tet-ON/OFF) conditional transgenic mouse (Tet-Nox2:VE-Cad-tTA) induces 1.8±0.42-fold increase in ROS in endothelium. Using these animals, we have examined the effects of short-term vs. the long-term effects of ROS on EC signaling, mitochondrial activity, and coronary endothelial function (microvessel reactivity). Isolated ECs from mouse heart showed that both short-term and long-term increase in ROS induced AMPK and eNOS, and nitric oxide (NO) synthesis, however, long-term increase in ROS abrogated these positive effects due to increased peroxynitrite levels and nitrotyration of MnSOD. Long-term ROS increase also results in mitochondrial membrane potential loss, reduction in mitochondrial content and EC function. Conclusion We report that whereas short-term increase in ROS is beneficial for EC function, long-term increase results in mitochondrial damage and inhibition of endothelial function." @default.
- W1003272834 created "2016-06-24" @default.
- W1003272834 creator A5012657061 @default.
- W1003272834 creator A5052281122 @default.
- W1003272834 creator A5073126091 @default.
- W1003272834 creator A5073422355 @default.
- W1003272834 creator A5074981426 @default.
- W1003272834 creator A5083654638 @default.
- W1003272834 creator A5087551058 @default.
- W1003272834 creator A5088180214 @default.
- W1003272834 date "2015-04-01" @default.
- W1003272834 modified "2023-10-15" @default.
- W1003272834 title "Oxidant‐induced Endothelial Dysfunction is a failure of the Mitochondria to Process Cytosolic ROS" @default.
- W1003272834 doi "https://doi.org/10.1096/fasebj.29.1_supplement.797.3" @default.
- W1003272834 hasPublicationYear "2015" @default.
- W1003272834 type Work @default.
- W1003272834 sameAs 1003272834 @default.
- W1003272834 citedByCount "0" @default.
- W1003272834 crossrefType "journal-article" @default.
- W1003272834 hasAuthorship W1003272834A5012657061 @default.
- W1003272834 hasAuthorship W1003272834A5052281122 @default.
- W1003272834 hasAuthorship W1003272834A5073126091 @default.
- W1003272834 hasAuthorship W1003272834A5073422355 @default.
- W1003272834 hasAuthorship W1003272834A5074981426 @default.
- W1003272834 hasAuthorship W1003272834A5083654638 @default.
- W1003272834 hasAuthorship W1003272834A5087551058 @default.
- W1003272834 hasAuthorship W1003272834A5088180214 @default.
- W1003272834 hasConcept C126322002 @default.
- W1003272834 hasConcept C134018914 @default.
- W1003272834 hasConcept C181199279 @default.
- W1003272834 hasConcept C185592680 @default.
- W1003272834 hasConcept C190283241 @default.
- W1003272834 hasConcept C203522944 @default.
- W1003272834 hasConcept C2775838275 @default.
- W1003272834 hasConcept C2776108821 @default.
- W1003272834 hasConcept C2776151105 @default.
- W1003272834 hasConcept C2778175917 @default.
- W1003272834 hasConcept C2778784160 @default.
- W1003272834 hasConcept C2779324830 @default.
- W1003272834 hasConcept C2779719074 @default.
- W1003272834 hasConcept C2780795997 @default.
- W1003272834 hasConcept C28859421 @default.
- W1003272834 hasConcept C48349386 @default.
- W1003272834 hasConcept C55493867 @default.
- W1003272834 hasConcept C71924100 @default.
- W1003272834 hasConcept C86803240 @default.
- W1003272834 hasConcept C95444343 @default.
- W1003272834 hasConceptScore W1003272834C126322002 @default.
- W1003272834 hasConceptScore W1003272834C134018914 @default.
- W1003272834 hasConceptScore W1003272834C181199279 @default.
- W1003272834 hasConceptScore W1003272834C185592680 @default.
- W1003272834 hasConceptScore W1003272834C190283241 @default.
- W1003272834 hasConceptScore W1003272834C203522944 @default.
- W1003272834 hasConceptScore W1003272834C2775838275 @default.
- W1003272834 hasConceptScore W1003272834C2776108821 @default.
- W1003272834 hasConceptScore W1003272834C2776151105 @default.
- W1003272834 hasConceptScore W1003272834C2778175917 @default.
- W1003272834 hasConceptScore W1003272834C2778784160 @default.
- W1003272834 hasConceptScore W1003272834C2779324830 @default.
- W1003272834 hasConceptScore W1003272834C2779719074 @default.
- W1003272834 hasConceptScore W1003272834C2780795997 @default.
- W1003272834 hasConceptScore W1003272834C28859421 @default.
- W1003272834 hasConceptScore W1003272834C48349386 @default.
- W1003272834 hasConceptScore W1003272834C55493867 @default.
- W1003272834 hasConceptScore W1003272834C71924100 @default.
- W1003272834 hasConceptScore W1003272834C86803240 @default.
- W1003272834 hasConceptScore W1003272834C95444343 @default.
- W1003272834 hasIssue "S1" @default.
- W1003272834 hasLocation W10032728341 @default.
- W1003272834 hasOpenAccess W1003272834 @default.
- W1003272834 hasPrimaryLocation W10032728341 @default.
- W1003272834 hasRelatedWork W1990811092 @default.
- W1003272834 hasRelatedWork W2009734791 @default.
- W1003272834 hasRelatedWork W2031601225 @default.
- W1003272834 hasRelatedWork W2168238309 @default.
- W1003272834 hasRelatedWork W2773663306 @default.
- W1003272834 hasRelatedWork W2904914030 @default.
- W1003272834 hasRelatedWork W2986056537 @default.
- W1003272834 hasRelatedWork W3092721208 @default.
- W1003272834 hasRelatedWork W3194998566 @default.
- W1003272834 hasRelatedWork W4295681828 @default.
- W1003272834 hasVolume "29" @default.
- W1003272834 isParatext "false" @default.
- W1003272834 isRetracted "false" @default.
- W1003272834 magId "1003272834" @default.
- W1003272834 workType "article" @default.