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- W1003290934 abstract "Signaling by human hepatocyte growth factor (hHGF) via its cell surface receptor (MET) drives mitogenesis, motogenesis and morphogenesis in a wide spectrum of target cell types and embryologic, developmental and homeostatic contexts. Oncogenic pathway activation also contributes to tumorigenesis and cancer progression, including tumor angiogenesis and metastasis, in several prevalent malignancies. The HGF gene encodes full-length hHGF and two truncated isoforms known as NK1 and NK2. NK1 induces all three HGF activities at modestly reduced potency, whereas NK2 stimulates only motogenesis and enhances HGF-driven tumor metastasis in transgenic mice. Prior studies have shown that mouse HGF (mHGF) also binds with high affinity to human MET. Here we show that, like NK2, mHGF stimulates cell motility, invasion and spontaneous metastasis of PC3M human prostate adenocarcinoma cells in mice through human MET. To identify target genes and signaling pathways associated with motogenic and metastatic HGF signaling, i.e., the HGF invasive program, gene expression profiling was performed using PC3M cells treated with hHGF, NK2 or mHGF. Results obtained using Ingenuity Pathway Analysis software showed significant overlap with networks and pathways involved in cell movement and metastasis. Interrogating The Cancer Genome Atlas project also identified a subset of 23 gene expression changes in PC3M with a strong tendency for co-occurrence in prostate cancer patients that were associated with significantly decreased disease-free survival." @default.
- W1003290934 created "2016-06-24" @default.
- W1003290934 creator A5019093460 @default.
- W1003290934 creator A5047843177 @default.
- W1003290934 creator A5059171574 @default.
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- W1003290934 creator A5088180023 @default.
- W1003290934 creator A5091688844 @default.
- W1003290934 creator A5091723132 @default.
- W1003290934 date "2015-08-01" @default.
- W1003290934 modified "2023-10-16" @default.
- W1003290934 title "Expression array analysis of the hepatocyte growth factor invasive program" @default.
- W1003290934 cites W117750355 @default.
- W1003290934 cites W145664544 @default.
- W1003290934 cites W1492343502 @default.
- W1003290934 cites W1522985778 @default.
- W1003290934 cites W1527752038 @default.
- W1003290934 cites W1536956249 @default.
- W1003290934 cites W1540415768 @default.
- W1003290934 cites W1544341564 @default.
- W1003290934 cites W1589271751 @default.
- W1003290934 cites W1593612940 @default.
- W1003290934 cites W1806087494 @default.
- W1003290934 cites W1839137025 @default.
- W1003290934 cites W1847790984 @default.
- W1003290934 cites W1849513387 @default.
- W1003290934 cites W1920441681 @default.
- W1003290934 cites W1964176624 @default.
- W1003290934 cites W1964697577 @default.
- W1003290934 cites W1965091140 @default.
- W1003290934 cites W1965357071 @default.
- W1003290934 cites W1969234635 @default.
- W1003290934 cites W1972564957 @default.
- W1003290934 cites W1976194946 @default.
- W1003290934 cites W1979445595 @default.
- W1003290934 cites W1980442141 @default.
- W1003290934 cites W1980556134 @default.
- W1003290934 cites W1983410692 @default.
- W1003290934 cites W1984291872 @default.
- W1003290934 cites W1985995844 @default.
- W1003290934 cites W1987727952 @default.
- W1003290934 cites W1988793342 @default.
- W1003290934 cites W1993264697 @default.
- W1003290934 cites W1995859737 @default.
- W1003290934 cites W1998396050 @default.
- W1003290934 cites W2000263623 @default.
- W1003290934 cites W2001268142 @default.
- W1003290934 cites W2002300983 @default.
- W1003290934 cites W2002376660 @default.
- W1003290934 cites W2003500892 @default.
- W1003290934 cites W2004277026 @default.
- W1003290934 cites W2005528673 @default.
- W1003290934 cites W2006738737 @default.
- W1003290934 cites W2009272688 @default.
- W1003290934 cites W2009697157 @default.
- W1003290934 cites W2014093464 @default.
- W1003290934 cites W2014822845 @default.
- W1003290934 cites W2015439707 @default.
- W1003290934 cites W2016124553 @default.
- W1003290934 cites W2017806952 @default.
- W1003290934 cites W2019998985 @default.
- W1003290934 cites W2022397091 @default.
- W1003290934 cites W2023139622 @default.
- W1003290934 cites W2023878886 @default.
- W1003290934 cites W2027337986 @default.
- W1003290934 cites W2029944582 @default.
- W1003290934 cites W2033695475 @default.
- W1003290934 cites W2036770679 @default.
- W1003290934 cites W2038681057 @default.
- W1003290934 cites W2040524925 @default.
- W1003290934 cites W2041705218 @default.
- W1003290934 cites W2043863662 @default.
- W1003290934 cites W2046643533 @default.
- W1003290934 cites W2050983091 @default.
- W1003290934 cites W2051025382 @default.
- W1003290934 cites W2051459755 @default.
- W1003290934 cites W2052591943 @default.
- W1003290934 cites W2052970381 @default.
- W1003290934 cites W2054042846 @default.
- W1003290934 cites W2060022144 @default.
- W1003290934 cites W2060596682 @default.
- W1003290934 cites W2061402441 @default.
- W1003290934 cites W2061872239 @default.
- W1003290934 cites W2062884952 @default.
- W1003290934 cites W2063956958 @default.
- W1003290934 cites W2066369326 @default.
- W1003290934 cites W2066749848 @default.
- W1003290934 cites W2066996101 @default.
- W1003290934 cites W2067975491 @default.
- W1003290934 cites W2068378027 @default.
- W1003290934 cites W2068474354 @default.
- W1003290934 cites W2068861828 @default.
- W1003290934 cites W2069498567 @default.
- W1003290934 cites W2069862324 @default.
- W1003290934 cites W2081485263 @default.
- W1003290934 cites W2085740859 @default.
- W1003290934 cites W2086992104 @default.
- W1003290934 cites W2087323952 @default.