Matches in SemOpenAlex for { <https://semopenalex.org/work/W100338727> ?p ?o ?g. }
- W100338727 abstract "The tumour suppressor gene PTEN is, next to p53, the second most frequently mutated gene in human cancers. The genes TSC1 and TSC2 are mutated in the severe human syndrome called Tuberous Sclerosis. Patients with this disease have large benign tumours composed of large cells in the brain. The genetic dissection of pathways controlling the growth of cells, organs, and the entire organism in Drosophila has contributed to the understanding of the signalling pathways that are controlled by these two tumour suppressors. Together with studies on nutrient regulation of growth and ageing in the nematode Caenorhabditis elegans, evidence from these model organisms has moved the Insulin/IGF (IIS) and the Target Rapamycin (TOR) signalling pathway onto the centre stage of cellular growth control and made them attractive novel targets for cancer therapy. In this review, I will outline the contributions of model organism genetics to the understanding of these disease relevant pathways and highlight the evolutionary conservation of nutrient-dependent growth regulation." @default.
- W100338727 created "2016-06-24" @default.
- W100338727 creator A5041130759 @default.
- W100338727 date "2004-12-11" @default.
- W100338727 modified "2023-10-03" @default.
- W100338727 title "Cancer, type 2 diabetes, and ageing: news from flies and worms" @default.
- W100338727 cites W1590458072 @default.
- W100338727 cites W1697523131 @default.
- W100338727 cites W1965495036 @default.
- W100338727 cites W1968220875 @default.
- W100338727 cites W1969967075 @default.
- W100338727 cites W1970212288 @default.
- W100338727 cites W1971556742 @default.
- W100338727 cites W1977128714 @default.
- W100338727 cites W1977747566 @default.
- W100338727 cites W1978625554 @default.
- W100338727 cites W1979612739 @default.
- W100338727 cites W1983247384 @default.
- W100338727 cites W1985425785 @default.
- W100338727 cites W1986458203 @default.
- W100338727 cites W1987942547 @default.
- W100338727 cites W1989324173 @default.
- W100338727 cites W1992326265 @default.
- W100338727 cites W1993672117 @default.
- W100338727 cites W1998038367 @default.
- W100338727 cites W1999123584 @default.
- W100338727 cites W2010909776 @default.
- W100338727 cites W2011282245 @default.
- W100338727 cites W2014887370 @default.
- W100338727 cites W2017882961 @default.
- W100338727 cites W2020891498 @default.
- W100338727 cites W2020936520 @default.
- W100338727 cites W2021660402 @default.
- W100338727 cites W2022309007 @default.
- W100338727 cites W2023819606 @default.
- W100338727 cites W2025693577 @default.
- W100338727 cites W2031452891 @default.
- W100338727 cites W2032685334 @default.
- W100338727 cites W2033429522 @default.
- W100338727 cites W2036056595 @default.
- W100338727 cites W2036254130 @default.
- W100338727 cites W2045201133 @default.
- W100338727 cites W2047683380 @default.
- W100338727 cites W2049009766 @default.
- W100338727 cites W2052578642 @default.
- W100338727 cites W2055248589 @default.
- W100338727 cites W2056137479 @default.
- W100338727 cites W2059729638 @default.
- W100338727 cites W2065887259 @default.
- W100338727 cites W2067458366 @default.
- W100338727 cites W2067655540 @default.
- W100338727 cites W2069988949 @default.
- W100338727 cites W2070119291 @default.
- W100338727 cites W2076352446 @default.
- W100338727 cites W2076684078 @default.
- W100338727 cites W2081526354 @default.
- W100338727 cites W2081969319 @default.
- W100338727 cites W2082853003 @default.
- W100338727 cites W2083850113 @default.
- W100338727 cites W2083919459 @default.
- W100338727 cites W2085819054 @default.
- W100338727 cites W2087136249 @default.
- W100338727 cites W2087221082 @default.
- W100338727 cites W2094941511 @default.
- W100338727 cites W2094957750 @default.
- W100338727 cites W2103304405 @default.
- W100338727 cites W2108478376 @default.
- W100338727 cites W2111125738 @default.
- W100338727 cites W2114713612 @default.
- W100338727 cites W2117257231 @default.
- W100338727 cites W2124898423 @default.
- W100338727 cites W2125861971 @default.
- W100338727 cites W2128557797 @default.
- W100338727 cites W2129585918 @default.
- W100338727 cites W2134975446 @default.
- W100338727 cites W2137035181 @default.
- W100338727 cites W2142276972 @default.
- W100338727 cites W2150123395 @default.
- W100338727 cites W2150418339 @default.
- W100338727 cites W2152289580 @default.
- W100338727 cites W2152600551 @default.
- W100338727 cites W2155783580 @default.
- W100338727 cites W2159990074 @default.
- W100338727 cites W2162857699 @default.
- W100338727 cites W2166208596 @default.
- W100338727 cites W27250448 @default.
- W100338727 cites W5894301 @default.
- W100338727 cites W90071970 @default.
- W100338727 cites W2159868799 @default.
- W100338727 doi "https://doi.org/10.4414/smw.2004.09885" @default.
- W100338727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15635489" @default.
- W100338727 hasPublicationYear "2004" @default.
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