Matches in SemOpenAlex for { <https://semopenalex.org/work/W1003981084> ?p ?o ?g. }
- W1003981084 abstract "Publisher Summary The emergence of new novel chemical classes of macrocyclic immunomodulators may provide a greater understanding of the factors that control the immune system. The prototype for such emerging class of agents is cyclosporin A (CsA). This chapter discusses the mechanism of action of CsA with a summary of the chemistry; in vitro and in vivo immunopharmacology and the mechanism of action of the newer macrocyclic immunomodulators, such as FK-506, rapamycin, and didemnins. FK-506, RPM, and didemnin B (DB) may be found to be safer and more efficacious agents for transplantation rejection and autoimmune disease than CsA. FK-506 and CsA both act by inhibiting the production of growth promoting lymphokines, although FK-506 is effective at much lower doses. RPM, although structurally similar to FK-506, acts by inhibiting the response of T cells to lymphokines. The mechanism of the action of DB remains unknown, but seems to be more antiproliferative than either FK-506 or RPM. The importance and relevance of immunophilins needs to be delineated, but they may have a role in immunological signal transduction. In addition or alternatively, the immunophilins may be involved in the renal or vascular toxicity observed with this emerging class of novel macrocyclic immunomodulatory agents." @default.
- W1003981084 created "2016-06-24" @default.
- W1003981084 creator A5031948511 @default.
- W1003981084 creator A5057684585 @default.
- W1003981084 date "1990-01-01" @default.
- W1003981084 modified "2023-09-24" @default.
- W1003981084 title "Chapter 21. Macrocyclic Immunomodulators" @default.
- W1003981084 cites W1234770814 @default.
- W1003981084 cites W1483749927 @default.
- W1003981084 cites W1517544303 @default.
- W1003981084 cites W1533596330 @default.
- W1003981084 cites W1551900159 @default.
- W1003981084 cites W1562075782 @default.
- W1003981084 cites W1608807138 @default.
- W1003981084 cites W183360860 @default.
- W1003981084 cites W1863217888 @default.
- W1003981084 cites W1966041651 @default.
- W1003981084 cites W1966859650 @default.
- W1003981084 cites W1967893873 @default.
- W1003981084 cites W1968619018 @default.
- W1003981084 cites W1972683791 @default.
- W1003981084 cites W1976129849 @default.
- W1003981084 cites W1976335974 @default.
- W1003981084 cites W1976726113 @default.
- W1003981084 cites W1977707793 @default.
- W1003981084 cites W1978879981 @default.
- W1003981084 cites W1987397384 @default.
- W1003981084 cites W1989175450 @default.
- W1003981084 cites W1990376530 @default.
- W1003981084 cites W1993870517 @default.
- W1003981084 cites W1994672839 @default.
- W1003981084 cites W2001881651 @default.
- W1003981084 cites W2002031038 @default.
- W1003981084 cites W2015407598 @default.
- W1003981084 cites W2016386333 @default.
- W1003981084 cites W2016618027 @default.
- W1003981084 cites W2016859588 @default.
- W1003981084 cites W2021399694 @default.
- W1003981084 cites W2022735531 @default.
- W1003981084 cites W2024305542 @default.
- W1003981084 cites W2025059799 @default.
- W1003981084 cites W2025897796 @default.
- W1003981084 cites W2030033469 @default.
- W1003981084 cites W2032139857 @default.
- W1003981084 cites W2032590795 @default.
- W1003981084 cites W2033008141 @default.
- W1003981084 cites W2034578360 @default.
- W1003981084 cites W2035936274 @default.
- W1003981084 cites W2036642007 @default.
- W1003981084 cites W2037521932 @default.
- W1003981084 cites W2046276016 @default.
- W1003981084 cites W2048965805 @default.
- W1003981084 cites W2052098699 @default.
- W1003981084 cites W2052431868 @default.
- W1003981084 cites W2052585707 @default.
- W1003981084 cites W2052741482 @default.
- W1003981084 cites W2055381555 @default.
- W1003981084 cites W2056897897 @default.
- W1003981084 cites W2058919422 @default.
- W1003981084 cites W2062120260 @default.
- W1003981084 cites W2066400597 @default.
- W1003981084 cites W2067504164 @default.
- W1003981084 cites W2070158185 @default.
- W1003981084 cites W2071369362 @default.
- W1003981084 cites W2076052277 @default.
- W1003981084 cites W2077140822 @default.
- W1003981084 cites W2079031041 @default.
- W1003981084 cites W2079199790 @default.
- W1003981084 cites W2081175933 @default.
- W1003981084 cites W2087269835 @default.
- W1003981084 cites W2088947878 @default.
- W1003981084 cites W2089850443 @default.
- W1003981084 cites W2089869923 @default.
- W1003981084 cites W2094633801 @default.
- W1003981084 cites W2111687259 @default.
- W1003981084 cites W2116331241 @default.
- W1003981084 cites W2116694288 @default.
- W1003981084 cites W2124233794 @default.
- W1003981084 cites W2135355823 @default.
- W1003981084 cites W2167839140 @default.
- W1003981084 cites W2272000518 @default.
- W1003981084 cites W2321489673 @default.
- W1003981084 cites W2321853548 @default.
- W1003981084 cites W2397547725 @default.
- W1003981084 cites W2402849175 @default.
- W1003981084 cites W2406553905 @default.
- W1003981084 cites W2410173404 @default.
- W1003981084 cites W2412312084 @default.
- W1003981084 cites W2413627709 @default.
- W1003981084 cites W2419019969 @default.
- W1003981084 cites W2462909917 @default.
- W1003981084 cites W2517054293 @default.
- W1003981084 cites W2626632314 @default.
- W1003981084 cites W2782175582 @default.
- W1003981084 cites W3024537208 @default.
- W1003981084 cites W309202309 @default.
- W1003981084 cites W42270971 @default.
- W1003981084 cites W75970960 @default.
- W1003981084 cites W2008405751 @default.
- W1003981084 cites W2050343949 @default.