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- W1004114529 abstract "Objectives Portal hypertension (PHT) is the main complication of cystic fibrosis liver disease (CFLD) but severe liver dysfunction occurred only in 0.5% of the patients. The early diagnosis of CFLD is elusive and a gold standard for diagnosis of liver disease is lacking. The aim of this study was to evaluate liver stiffness measurement (LSM) and CT with IV injected contrast medium in CF adult patients. Median LSM in 241 CF patients was 5.9 kPa. Methods 57 CF patients (28F, 33 yrs −18; 51) had LSM and CT done for lung transplant assessement or after lung transplantation. Results LSM was obtained in 53 patients (92%). PHT was evident on CT in 25 patients (portosystemic collaterals 12, splenomegaly 19, proeminent portal vein 25). PHT was present in 60% of the patients when LSM was >5.9 and in 12% when LSM was Conclusion CFLD with PHT could be present in patient with low LSM. Decompensation of PHT is unfrequent even in adults with end stage pulmonary disease or after lung transplantation. Portal venopathy without cirrhosis could explain PHT. The mechanism remains obscure but could explain the rare occurence of hepatocellular deficiency in CFLD." @default.
- W1004114529 created "2016-06-24" @default.
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- W1004114529 date "2015-06-01" @default.
- W1004114529 modified "2023-10-17" @default.
- W1004114529 title "WS16.4 Non invasive liver elastography (LSM) and computed tomography (CT) for evaluation of liver disease in 57 cystic fibrosis adult patients" @default.
- W1004114529 doi "https://doi.org/10.1016/s1569-1993(15)30093-x" @default.
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