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- W1004492912 abstract "This review summarizes current data on the epidemiology, pathophysiology, and treatment of hypertension (HTN) in children with end-stage renal disease (ESRD). Worldwide prevalence of ESRD ranges from 5.0 to 84.4 per million age-related population. HTN is present in 27-79% of children with ESRD, depending on the modality of renal replacement therapy and the exact definition of hypertension. Ambulatory BP monitoring has been recommended for the detection of HTN and evaluation of treatment effectiveness. HTN in dialyzed patients is mostly related to hypervolemia, sodium overload, activation of the renin-angiotensin-aldosterone system (RAAS) and sympathetic nervous system, impaired nitric oxide synthesis, reduced vitamin D levels, and effects of microRNA. In children undergoing chronic dialysis therapy, important factors include optimization of renal replacement therapy and preservation of residual renal function, allowing reduction of volume- and sodium-overload, along with appropriate drug treatment, particularly with calcium channel blockers, RAAS inhibitors, and loop diuretics." @default.
- W1004492912 created "2016-06-24" @default.
- W1004492912 creator A5058483463 @default.
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- W1004492912 date "2015-09-01" @default.
- W1004492912 modified "2023-09-22" @default.
- W1004492912 title "Hypertension in children with end-stage renal disease" @default.
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- W1004492912 doi "https://doi.org/10.1016/j.advms.2015.07.001" @default.
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