FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1005020525> ?p ?o ?g. }

• W1005020525 endingPage "72" @default.
• W1005020525 startingPage "64" @default.
• W1005020525 abstract "We investigated the effects of pramipexole, a potent dopamine receptor D2/D3 agonist, on light-induced retinal damage in mice, H2O2-induced retinal pigment epithelium ARPE-19 cell injury in humans, and hydroxyl radical scavenging activity in a cell-free system. Pramipexole (0.1 and 1 mg/kg body weight) was orally administered to mice 1 h before light exposure (5000 lux, 2 h). Electrophysiological and morphologic studies were performed to evaluate the effects of the pramipexole on light-induced retinal damage in mice. Pramipexole significantly prevented the reduction of the a- and b-wave electroretinogram (ERG) amplitudes caused by light exposure in a dose-dependent manner. In parallel, damage to the inner and outer segments (IS/OS) of the photoreceptors, loss of photoreceptor nuclei, and the number of Tdt-mediated dUTP nick-end labeling (TUNEL)-positive cells in the outer nuclear layer (ONL) caused by light exposure were notably ameliorated by pramipexole. Additionally, pramipexole suppressed H2O2-induced ARPE-19 cell death in vitro in a concentration-dependent manner. The effect of pramipexole was significant at concentrations of 10(-6) M or higher. Pramipexole also significantly prevented H2O2-induced activation of caspases-3/7 and the intracellular accumulation of reactive oxygen species (ROS) in a concentration-dependent manner ranging from 10(-5) to 10(-3) M. Furthermore, pramipexole increased the scavenging activity toward a hydroxyl radical generated from H2O2 in a Fenton reaction. Our results suggest that pramipexole protects against light-induced retinal damage as an antioxidant and that it may be a novel and effective therapy for retinal degenerative disorders, such as dry age-related macular degeneration." @default.
• W1005020525 created "2016-06-24" @default.
• W1005020525 creator A5003748695 @default.
• W1005020525 creator A5009516767 @default.
• W1005020525 creator A5056162918 @default.
• W1005020525 creator A5080198375 @default.
• W1005020525 date "2015-10-01" @default.
• W1005020525 modified "2023-09-25" @default.
• W1005020525 title "Beneficial protective effect of pramipexole on light-induced retinal damage in mice" @default.
• W1005020525 cites W1512942014 @default.
• W1005020525 cites W1964396662 @default.
• W1005020525 cites W1970668683 @default.
• W1005020525 cites W1974296683 @default.
• W1005020525 cites W1978406998 @default.
• W1005020525 cites W1988410112 @default.
• W1005020525 cites W1989385887 @default.
• W1005020525 cites W1990886939 @default.
• W1005020525 cites W1994867460 @default.
• W1005020525 cites W1998280642 @default.
• W1005020525 cites W1999753474 @default.
• W1005020525 cites W2006538908 @default.
• W1005020525 cites W2014575812 @default.
• W1005020525 cites W2019962808 @default.
• W1005020525 cites W2020386405 @default.
• W1005020525 cites W2022073599 @default.
• W1005020525 cites W2027716003 @default.
• W1005020525 cites W2029973048 @default.
• W1005020525 cites W2035417313 @default.
• W1005020525 cites W2043410669 @default.
• W1005020525 cites W2053517908 @default.
• W1005020525 cites W2057810684 @default.
• W1005020525 cites W2060806180 @default.
• W1005020525 cites W2061505900 @default.
• W1005020525 cites W2062577694 @default.
• W1005020525 cites W2067236310 @default.
• W1005020525 cites W2071478026 @default.
• W1005020525 cites W2073280663 @default.
• W1005020525 cites W2077036305 @default.
• W1005020525 cites W2083242977 @default.
• W1005020525 cites W2085872894 @default.
• W1005020525 cites W2088312101 @default.
• W1005020525 cites W2091404872 @default.
• W1005020525 cites W2094613097 @default.
• W1005020525 cites W2109747317 @default.
• W1005020525 cites W2110252008 @default.
• W1005020525 cites W2112146496 @default.
• W1005020525 cites W2117917811 @default.
• W1005020525 cites W2119683782 @default.
• W1005020525 cites W2123554280 @default.
• W1005020525 cites W2124415048 @default.
• W1005020525 cites W2128796239 @default.
• W1005020525 cites W2131534997 @default.
• W1005020525 cites W2141933914 @default.
• W1005020525 cites W2147073426 @default.
• W1005020525 cites W2156252190 @default.
• W1005020525 cites W2598520882 @default.
• W1005020525 doi "https://doi.org/10.1016/j.exer.2015.07.007" @default.
• W1005020525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26213307" @default.
• W1005020525 hasPublicationYear "2015" @default.
• W1005020525 type Work @default.
• W1005020525 sameAs 1005020525 @default.
• W1005020525 citedByCount "24" @default.
• W1005020525 countsByYear W10050205252016 @default.
• W1005020525 countsByYear W10050205252017 @default.
• W1005020525 countsByYear W10050205252018 @default.
• W1005020525 countsByYear W10050205252019 @default.
• W1005020525 countsByYear W10050205252020 @default.
• W1005020525 countsByYear W10050205252021 @default.
• W1005020525 countsByYear W10050205252022 @default.
• W1005020525 countsByYear W10050205252023 @default.
• W1005020525 crossrefType "journal-article" @default.
• W1005020525 hasAuthorship W1005020525A5003748695 @default.
• W1005020525 hasAuthorship W1005020525A5009516767 @default.
• W1005020525 hasAuthorship W1005020525A5056162918 @default.
• W1005020525 hasAuthorship W1005020525A5080198375 @default.
• W1005020525 hasConcept C12554922 @default.
• W1005020525 hasConcept C126322002 @default.
• W1005020525 hasConcept C185592680 @default.
• W1005020525 hasConcept C2778004101 @default.
• W1005020525 hasConcept C2779134260 @default.
• W1005020525 hasConcept C2779734285 @default.
• W1005020525 hasConcept C2779989193 @default.
• W1005020525 hasConcept C2780369685 @default.
• W1005020525 hasConcept C2780827179 @default.
• W1005020525 hasConcept C48349386 @default.
• W1005020525 hasConcept C55493867 @default.
• W1005020525 hasConcept C71924100 @default.
• W1005020525 hasConcept C86803240 @default.
• W1005020525 hasConcept C98274493 @default.
• W1005020525 hasConceptScore W1005020525C12554922 @default.
• W1005020525 hasConceptScore W1005020525C126322002 @default.
• W1005020525 hasConceptScore W1005020525C185592680 @default.
• W1005020525 hasConceptScore W1005020525C2778004101 @default.
• W1005020525 hasConceptScore W1005020525C2779134260 @default.
• W1005020525 hasConceptScore W1005020525C2779734285 @default.
• W1005020525 hasConceptScore W1005020525C2779989193 @default.
• W1005020525 hasConceptScore W1005020525C2780369685 @default.
• W1005020525 hasConceptScore W1005020525C2780827179 @default.

• next