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• W1005028082 abstract "Research Article15 April 1994free access Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23. C. Masutani C. Masutani Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author K. Sugasawa K. Sugasawa Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author J. Yanagisawa J. Yanagisawa Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author T. Sonoyama T. Sonoyama Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author M. Ui M. Ui Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author T. Enomoto T. Enomoto Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author K. Takio K. Takio Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author K. Tanaka K. Tanaka Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author P.J. van der Spek P.J. van der Spek Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author D. Bootsma D. Bootsma Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author C. Masutani C. Masutani Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author K. Sugasawa K. Sugasawa Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author J. Yanagisawa J. Yanagisawa Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author T. Sonoyama T. Sonoyama Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author M. Ui M. Ui Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author T. Enomoto T. Enomoto Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author K. Takio K. Takio Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author K. Tanaka K. Tanaka Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author P.J. van der Spek P.J. van der Spek Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author D. Bootsma D. Bootsma Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. Search for more papers by this author Author Information C. Masutani1, K. Sugasawa1, J. Yanagisawa1, T. Sonoyama1, M. Ui1, T. Enomoto1, K. Takio1, K. Tanaka1, P.J. Spek1 and D. Bootsma1 1Cellular Physiology Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan. The EMBO Journal (1994)13:1831-1843https://doi.org/10.1002/j.1460-2075.1994.tb06452.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Complementation group C of xeroderma pigmentosum (XP) represents one of the most common forms of this cancer-prone DNA repair syndrome. The primary defect is located in the subpathway of the nucleotide excision repair system, dealing with the removal of lesions from the non-transcribing sequences (‘genome-overall’ repair). Here we report the purification to homogeneity and subsequent cDNA cloning of a repair complex by in vitro complementation of the XP-C defect in a cell-free repair system containing UV-damaged SV40 minichromosomes. The complex has a high affinity for ssDNA and consists of two tightly associated proteins of 125 and 58 kDa. The 125 kDa subunit is an N-terminally extended version of previously reported XPCC gene product which is thought to represent the human homologue of the Saccharomyces cerevisiae repair gene RAD4. The 58 kDa species turned out to be a human homologue of yeast RAD23. Unexpectedly, a second human counterpart of RAD23 was identified. All RAD23 derivatives share a ubiquitin-like N-terminus. The nature of the XP-C defect implies that the complex exerts a unique function in the genome-overall repair pathway which is important for prevention of skin cancer. Previous ArticleNext Article Volume 13Issue 81 April 1994In this issue RelatedDetailsLoading ..." @default.
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• W1005028082 title "Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23." @default.
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• W1005028082 doi "https://doi.org/10.1002/j.1460-2075.1994.tb06452.x" @default.
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