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- W1005458512 abstract "The present study established a rabbit model of global cerebral ischemia using the 'six-vessel' method, which was reperfused after 30 minutes of ischemia. Rabbits received intravenous injection of propofol at 5 mg/kg prior to ischemia and 20 mg/kg per hour after ischemia until samples were prepared. Results revealed that propofol inhibited serum interleukin-8, endothelin-1 and malondialdehyde increases and promoted plasma superoxide dismutase activity after cerebral ischemia/reperfusion. In addition, cerebral cortex edema was attenuated with little neuronal nuclear degeneration and pyknosis with propofol treatment. The cross-sectional area of neuronal nuclei was, however, increased following propofol treatment. These findings suggested that propofol could improve anti-oxidant activity and inhibit synthesis of inflammatory factors to exert a protective effect on cerebral ischemia/reperfusion injury." @default.
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- W1005458512 date "2012-04-15" @default.
- W1005458512 modified "2023-10-16" @default.
- W1005458512 title "Propofol inhibits inflammation and lipid peroxidation following cerebral ischemia/reperfusion in rabbits." @default.
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- W1005458512 doi "https://doi.org/10.3969/j.issn.1673-5374.2012.11.007" @default.
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