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- W10055105 abstract "Abstract The main psychoactive ingredient of Cannabis sativa, Δ9-tetrahydrocannabinol (THC) produces complex modulatory effects on emotional states in humans and laboratory animals. The characterization of the receptors activated by THC and their endogenous ligands (endocannabinoids) has initiated numerous studies exploring the functions of the endocannabinoid system and its impact on anxiety-related and emotional responses. These studies, which have been facilitated by the development of selective pharmacological tools and genetically engineered mice, have led to recognize that the endocannabinoid system plays an important role in the regulation of emotional states. However, its impact on anxiety-related behaviors is highly variable, probably depending on the involvement of different receptors, brain regions and neurotransmitter systems. Furthermore, numerous factors contribute to modulate the role of endocannabinoids on anxiety, such as genetic background, age, sex and situational context. Under specific environmental circumstances, pharmacological enhancement of endocannabinoid signaling has indeed been shown to produce anxiolytic-like and mood-enhancing functions in rodents, without causing the wide spectrum of untoward behavioral responses induced by THC and other cannabinoid agonists. Thus, endocannabinoid system might be a novel pharmacological target for anti-anxiety therapy. Here we provide a comprehensive overview on the current state of knowledge of the involvement of endocannabinoid system in anxiety-related responses and highlight the present challenges of research in this field as well as the novel perspectives offered by this system in the therapy of anxiety disorders." @default.
- W10055105 created "2016-06-24" @default.
- W10055105 creator A5031213755 @default.
- W10055105 creator A5046921350 @default.
- W10055105 date "2008-01-01" @default.
- W10055105 modified "2023-09-26" @default.
- W10055105 title "Chapter 4.5 The endocannabinoid system and anxiety responses" @default.
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