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• W1005575307 abstract "The investigation of uptake mechanisms for cell-penetrating peptides (CPPs) is and has been an ongoing project for as long as the peptides have been known, a time period that now spans over two decades. The ultimate answer is yet to be revealed and the current understanding is that no one mechanism will ever be found. The reason for this is that the uptake mechanism seems to be dependent on a multitude of factors that include which CPP, what cells are used, whether or not there is cargo and what the cargo is. CPPs are capable of delivering a variety of bio-macromolecules that are by themselves unable to enter into cells. Our group has reported on many different peptides in recent years, many aimed at delivering various oligonucleotide-based cargoes. These peptides have utilized the inherent positive charge of the peptides and some rationally designed modifications to non-covalently complex oligonucleotides and bring them into cells. In this chapter, we present a brief overview of the current proposals for the uptake mechanisms of CPPs and describe methods for detecting and evaluating the role of scavenger receptor class A receptors in the uptake of non-covalent cell-penetrating peptide:oligonucleotide complexes." @default.
• W1005575307 created "2016-06-24" @default.
• W1005575307 creator A5002574049 @default.
• W1005575307 creator A5046083680 @default.
• W1005575307 creator A5057501316 @default.
• W1005575307 date "2015-01-01" @default.
• W1005575307 modified "2023-09-26" @default.
• W1005575307 title "SCARA Involvement in the Uptake of Nanoparticles Formed by Cell-Penetrating Peptides" @default.
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• W1005575307 doi "https://doi.org/10.1007/978-1-4939-2806-4_11" @default.
• W1005575307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26202269" @default.
• W1005575307 hasPublicationYear "2015" @default.
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