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• W10058053 abstract "Experimental in vitro or in vivo studies have shown that striatum is specially vulnerable to hypoxia. In this brain area, deep hypoxic episodes, as those encountered in ischemia/anoxia, lead to a neuronal loss (Banasiak et al. 2000; Tuor et al. 2001) which is thought to be linked to an enhanced release of neurotransmitters, mainly dopamine (DA) and glutamate (Glu) (Globus et al 1995; Kunimatsu et al. 1999; Nakajima et al. 1996; Szatkowski and Attwell, 1994; Wang et al. 1995). However, tolerable hypoxaemic hypoxia can also affect striatum. This type of hypoxia occurs in environmental oxygen concentration (FiO2) of 10-12% or even lower, e.g. during life in altitude or in several pathological states such as respiratory insufficiency. Although tolerable hypoxic exposure does not lead to apparent alterations in energy metabolism of the brain (Duffy et al. 1975; Norberg and Siesjô, 1975) and does not induce any neuronal loss (Miyamoto and Auer, 2000), it produces behavioral disturbances in animals (Brown and Engel, 1973; Speiser et al. 1990), which may be linked to alterations in striatal neurotransmission. Indeed, in vivo extracellular DA concentration is increased by tolerable hypoxia in the striatum of freely-moving adult rats (Akiyama et al. 1991) or rat pups (Nakajima et al. 1996). In contrast to DA, alterations in excitatory amino acid neurotransmission during tolerable hypoxia are poorly documented. Although Glu concentration has been reported to be increased in striatal tissue from rat pups (Krajnc et al. 1996), in vivo studies performed on ventilated anaesthetised animals failed to show any change in extracellular Glu during acute tolerable hypoxia (Kunimatsu et al. 1999; Pastuszko, 1994). However, these latter studies could have missed changes since anaesthetics can influence extracellular Glu (Rozza et al. 2000; Shiraishi et al. 1997). Moreover, these former data give only partial information on amino acid neurotransmission, since the extracellular concentration of Asp, the second excitatory amino acid which may exhibit different alterations than Glu in some pathophysiological conditions (Abarca and Bustos, 1999), was not monitored." @default.
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• W10058053 date "2003-01-01" @default.
• W10058053 modified "2023-09-23" @default.
• W10058053 title "Effects of Acute Hypoxic Conditions on Extracellular Excitatory Amino Acids and Dopamine in the Striatum of Freely-moving Rats" @default.
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• W10058053 doi "https://doi.org/10.1007/978-1-4419-9280-2_55" @default.
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