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- W100635035 abstract "Since small-bowel transplantation was first described. experimentally in the late 1950s, control of graft rejection has been recognized as the primary obstacle to its successful Clinical implementation. Early experimental and clinical studies demonstrated that immunosuppressive regimens based upon azathioprine, antilymphocyte globulin, and corticosteroids were not sufficient to ensure long-term recipient and graft survival. More recently long-term functional survival of intestinal allografts has been achieved with cyclosporine in. a variety of experimental animal models and has led to renewed attempts at clinical small-bowel transplantation. Although long-term survival has been achieved in some instances, prevention of graft rejection remains a major problem.The neutral macrolide FK 506 has been shown on a molar basis to be a more potent inhibitor of in vivo and in vitro assays of immune function than cyclosporine.1 It has also been shown to significantly delay rejection of kidney,2 heart,3 and liver4 allografts in a number of different experimental models. A rat model was therefore used to study the effectiveness of FK 506 in prolonging the survival of intestinal allografts and to compare its effectiveness with that observed for cyclosporine." @default.
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- W100635035 date "1990-12-01" @default.
- W100635035 modified "2023-09-23" @default.
- W100635035 title "Comparison of short-term immunosuppressive therapy with cyclosporine and FK 506 in small-bowel transplantation." @default.
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