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- W1006539672 abstract "[Objective] To clone the full-length gene of Toll-like receptors(TLRs) in Paralichthys olivaceus,and analyze their structural features and expression rules.[Method] The full-length cDNA sequence of Toll like receptor 1(TLR1) gene was identified from Paralichthys olivaceus head kidney by homologous cloning and rapid amplification cDNA ends(RACE).And then the bioinformatics and expression model of this gene were analyzed.[Result] The TLR1 cDNA was 2 947 bp,an 2 418 bp open reading frame(ORF),encoding 805 amino acid(aa) residues,including signal peptide,6 leucine rich repeat(LRR) motifs,two transmembrane zones and one Toll/IL 1 receptor(TIR) domain.The molecular weight of the deduced protein was 91.15 kDa,and the isoelectric point was 6.49.The amino acid sequence of JfTLR1 possessed 69%-35% identity with the TLR1s of other vertebrates,further analysis showed that the TIR domain of JfTLR1 shared 84%-62% identities with TIR domains in other vertebrates.JfTLR1 protein firstly clustered with TLR1s in Epinephelus coioides in the phylogenetic analysis.The transcription of JfTLR1 was examined by real-time quantitative PCR,and its mRNA was mainly expressed in liver,heart and spleen.[Conclusion] The results lay a foundation for furthur studying the functions of TLR1 and exploiting the immune potentiator in Paralichthys olivaceus." @default.
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- W1006539672 date "2012-01-01" @default.
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- W1006539672 title "Molecular cloning and expression analysis of toll-like receptor 1 cDNA in Japanese flounder, Paralichthys olivaceus." @default.
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