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- W100710130 endingPage "320" @default.
- W100710130 startingPage "299" @default.
- W100710130 abstract "Resistance development is a major obstacle to antiviral therapy, and all active antiviral agents have shown to select for resistance mutations. Aspects of antiviral resistance development are discussed for specific compounds or drug classes in the previous chapters, while this chapter provides an overview regarding the evolution of different viruses (HIV, HBV, HCV, and Influenza) under pressure of antiviral therapy. Virus replication is an error prone process resulting in a large number of variants (quasispecies) in patients. Resistance evolution under suboptimal therapy can be schematically distinguished into three phases. (1) preexisting variants less sensitive to the respective drug are selected from the quasispecies population, (2) outgrowing variants acquire additional mutations increasing their resistance, and (3) compensatory mutations accumulate to overcome the generally reduced replicative capacity of resistant variants. Successful therapy should be aimed at suppression of all existing viral variants, thus preventing selection of minority species and their subsequent evolution. This implies that the amount of mutations required for first escape to the viral regimen (genetic barrier) should be larger than the expected number of mutations present in viruses in the quasispecies. Accordingly, combination therapy can achieve complete inhibition of replication for most HIV, HBV, and Influenza infected patients without resistance development. However, resistant viruses can become selected under circumstances of suboptimal antiviral therapy and these resistant viruses can be transmitted. Proper use of drugs and worldwide monitoring for the presence and spread of drug resistant viruses are therefore of utmost importance." @default.
- W100710130 created "2016-06-24" @default.
- W100710130 creator A5002497082 @default.
- W100710130 creator A5032201935 @default.
- W100710130 creator A5048537587 @default.
- W100710130 date "2008-12-01" @default.
- W100710130 modified "2023-10-16" @default.
- W100710130 title "Antiviral Resistance and Impact on Viral Replication Capacity: Evolution of Viruses Under Antiviral Pressure Occurs in Three Phases" @default.
- W100710130 cites W1531777139 @default.
- W100710130 cites W1595757174 @default.
- W100710130 cites W1616616802 @default.
- W100710130 cites W1898585322 @default.
- W100710130 cites W1964963193 @default.
- W100710130 cites W1967579117 @default.
- W100710130 cites W1972613143 @default.
- W100710130 cites W1973984443 @default.
- W100710130 cites W1977279184 @default.
- W100710130 cites W1984898374 @default.
- W100710130 cites W1987858510 @default.
- W100710130 cites W1995565071 @default.
- W100710130 cites W1997809789 @default.
- W100710130 cites W1998756597 @default.
- W100710130 cites W2007682399 @default.
- W100710130 cites W2009428685 @default.
- W100710130 cites W2014626538 @default.
- W100710130 cites W2016449892 @default.
- W100710130 cites W2017953463 @default.
- W100710130 cites W2020234447 @default.
- W100710130 cites W2020760853 @default.
- W100710130 cites W2027543203 @default.
- W100710130 cites W2028873388 @default.
- W100710130 cites W2030512748 @default.
- W100710130 cites W2031807740 @default.
- W100710130 cites W2032471469 @default.
- W100710130 cites W2033944249 @default.
- W100710130 cites W2033978085 @default.
- W100710130 cites W2037245607 @default.
- W100710130 cites W2037450520 @default.
- W100710130 cites W2038729300 @default.
- W100710130 cites W2052200516 @default.
- W100710130 cites W2052700689 @default.
- W100710130 cites W2058376942 @default.
- W100710130 cites W2061505027 @default.
- W100710130 cites W2069854242 @default.
- W100710130 cites W2075704126 @default.
- W100710130 cites W2077196854 @default.
- W100710130 cites W2079257001 @default.
- W100710130 cites W2082953408 @default.
- W100710130 cites W2083615827 @default.
- W100710130 cites W2088631360 @default.
- W100710130 cites W2091262391 @default.
- W100710130 cites W2096070610 @default.
- W100710130 cites W2096820612 @default.
- W100710130 cites W2097641909 @default.
- W100710130 cites W2104866417 @default.
- W100710130 cites W2106197195 @default.
- W100710130 cites W2110747022 @default.
- W100710130 cites W2110941134 @default.
- W100710130 cites W2111610276 @default.
- W100710130 cites W2111736586 @default.
- W100710130 cites W2113154128 @default.
- W100710130 cites W2116584773 @default.
- W100710130 cites W2119319706 @default.
- W100710130 cites W2119855246 @default.
- W100710130 cites W2120267205 @default.
- W100710130 cites W2122858451 @default.
- W100710130 cites W2123543307 @default.
- W100710130 cites W2124394465 @default.
- W100710130 cites W2127923731 @default.
- W100710130 cites W2129728733 @default.
- W100710130 cites W2130441728 @default.
- W100710130 cites W2134381174 @default.
- W100710130 cites W2138056007 @default.
- W100710130 cites W2138602400 @default.
- W100710130 cites W2139167304 @default.
- W100710130 cites W2145899386 @default.
- W100710130 cites W2148291080 @default.
- W100710130 cites W2148314825 @default.
- W100710130 cites W2148684707 @default.
- W100710130 cites W2149087734 @default.
- W100710130 cites W2152283024 @default.
- W100710130 cites W2154288940 @default.
- W100710130 cites W2156027719 @default.
- W100710130 cites W2157177671 @default.
- W100710130 cites W2157791496 @default.
- W100710130 cites W2163606686 @default.
- W100710130 cites W2164368077 @default.
- W100710130 cites W2168912424 @default.
- W100710130 cites W2170219825 @default.
- W100710130 cites W2316425515 @default.
- W100710130 cites W2334277624 @default.
- W100710130 cites W2418706749 @default.
- W100710130 cites W2911949936 @default.
- W100710130 cites W41880533 @default.
- W100710130 cites W94004259 @default.
- W100710130 doi "https://doi.org/10.1007/978-3-540-79086-0_11" @default.
- W100710130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19048205" @default.
- W100710130 hasPublicationYear "2008" @default.