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- W1007200210 abstract "s3-2Flow cytometry can immunophenotype cells and assess expression of a limited number of molecules/cell, and the Biacore and Flexchip systems can quantify protein-protein or protein-oligonucleotide interactions. However, there are currently few systems that can quantify cell function in a microfluidic system that is combined with multiplexed analyte measurements. A novel technology capable of assaying different structural and functional characteristics of cells, using blood leukocytes as a prototype cell population, will be described. This chip-based system for functional and phenotypic cell analysis that is based on surface plasmon enhanced plasmonics. Since this microchip assay system is miniaturized, small volumes of blood and minimal amounts of reagents are consumed in the analyses. In this system, multiple different leukocyte subpopulations can be individually captured by antibodies or by MHC/peptide conjugates on a single sensor chip surface. The functional activities of these captured cells can be quantified in real-time by SPEF measurements of cytokines and other secreted proteins. This system also can be adapted to sort cells followed by characterization, which is suggested to be useful for circulating tumor cell assessment. Modifications of this system that incorporating an microcapillary system for chemotaxis also will be described. There is potential for these multiplexed microarray systems in the analysis of biomarker disease signatures, the potential for prognosis of disease processes, and the consequences of disease manipulation." @default.
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- W1007200210 date "2010-09-01" @default.
- W1007200210 modified "2023-09-23" @default.
- W1007200210 title "Miniaturized Systems for Cell-based Assays." @default.
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