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• W1007388605 abstract "The aim of this study was to analyse the possible association between no success of dental implants and two polymorphisms, IL1A (_889) and IL1B (+3953), in a Caucasian Portuguese population, and a possible relationship with other potential risk variables associated with a peri-implant disease. INTRODUCTION The use of dental implants by dentists for oral rehabilitation has been assuming an increasing importance given the evolution and diversity of systems of implants and the demands of satisfaction from patients. However, it is an issue that still raise some questions in understanding some phenomena of failure and biological complications, which at first sight is inexplicable and unpredictable. Pathogenic bacteria and other factors like biomechanical overload, history of periodontitis, smoking habit, alcohol consumption and genetic variants (polymorphisms) have been suggested in the pathogenesis of biological periimplant complications (Wilson & Nunn 1999; Rogers, 2002; Cury, 2009; Dirschnabel, 2011; Vaz, 2011). It is essential to clarify the clinical value of these genetic variants in the rehabilitation with dental implants. 155 unrelated Caucasian individuals were divided into 2 groups: 100 with successful dental implant rehabilitations and 55 with unsuccessful ones. To identify the polymorphisms, in positions -889 of IL1A gene and +3953 of IL1B gene, was performed an oral mucosa scraping of the patients and the DNA obtained from epithelial cells. The data were analysed in the SPSS Statistics 17.0® and the statistic analysis included the independence test of the chisquare, the exact test of Fisher and techniques of analysis of binary logistic regression. RESULTS AND CONCLUSIONS The estimated prevalence of polymorphisms of IL1A and IL1B gene, determined by the TGP (CGC Genetics, Portugal) results, in the Caucasian Portuguese population was of 33.5% (Table 1). Success of rehabilitation with dental implants was more associated to a negative TGP result, whereas failure was found to be related to a positive result. Porto/Portugal, 22-27 July 2012 2 Tobacco (tobacco 1, OR = 0.995, P-value = 0.982; tobacco 2, OR = 0.953, P-value = 0.817; tobacco 3, OR = 0.907, P-value = 0.477) and alcohol (wine, OR = 0.890, P-value = 0.732; beer, OR =0.857, P-value = 0.728; spirits and liquors, OR = 0.878, P-value = 0.788) consumption showed no statistically significant association with success or no success of the dental implants. Table 1 Prevalence of TGP result and allelic combinations studied in the sample" @default.
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• W1007388605 date "2012-01-01" @default.
• W1007388605 modified "2023-09-23" @default.
• W1007388605 title "Protocol of BRONJ prevention: successful use of antiseptics during oral surgical procedures" @default.
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• W1007388605 doi "https://doi.org/10.1111/j.1600-051x-2012.01890.x" @default.
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