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- W1007424240 endingPage "321" @default.
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- W1007424240 abstract "The two major gastrointestinal hormones, gastrin and cholecystokinin (CCK), were discovered at the beginning of this century. In the immediate wake of Bayliss and Starling’s breakthrough discovery of secretin — the first hormone to be known (1902) — Edkins from the same institute in London suggested that the antral mucosa of the stomach released a specific gastric acid stimulating factor to blood. He named the factor gastrin, an abbreviation of “gastric secretin” (Edkins 1905). Hence, gastrin was the second peptide hormone to be discovered in the history of biology. Twenty three years after Edkins’ discovery, Ivy and Oldberg in Chicago found the third gastrointestinal hormone, CCK, as a new gallbladder emptying factor present in extracts of the small intestinal mucosa (1928). The painstaking efforts to purify and identify the structure of secretin and CCK began in the middle of this century in Stockholm. During this work Jorpes and Mutt (1966) realized that CCK is identical to pancreozymin, the fourth gastrointestinal hormone, which was described by Harper and Raper from Newcastle-upon-Tyne (1943). Pancreozymin regulates the exocrine secretion of enzymes from the pancreas." @default.
- W1007424240 created "2016-06-24" @default.
- W1007424240 creator A5091673364 @default.
- W1007424240 date "1999-01-01" @default.
- W1007424240 modified "2023-10-18" @default.
- W1007424240 title "The Cholecystokinin — Gastrin Family of Peptides and Their Receptors" @default.
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