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- W100758498 abstract "ABSTRACT The suitability of quantitative EEG methodologies in the estimation of cerebral bioavailability and central action of antiepileptic compounds has been tested in 44 patients during single-drug therapy with ethosuximide, diphenylhydantoin, valproic acid, or phenobarbital. Clinical conditions were monitored, and EEG and plasma samples were collected periodically during long-term treatment. The background EEG activity was quantified by spectral power analysis on signal epochs free from specific epileptic phenomena. Drug plasma concentrations were determined by gas liquid chromatographic methods. Consistent EEG modifications were observed during treatment with ethosuximide, valproic acid and phenobarbital, and found to be related to plasma concentration only in the case of phenobarbital. No changes were detected during therapy with diphenylhydantoin." @default.
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- W100758498 date "1979-01-01" @default.
- W100758498 modified "2023-09-27" @default.
- W100758498 title "Quantitative EEG in Relation to Plasma Concentration During Treatment with Antiepileptic Drugs" @default.
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- W100758498 doi "https://doi.org/10.1016/b978-0-08-023089-4.50047-8" @default.
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