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- W100774288 abstract "Quercetin is a flavonol with broad spectrum bioactive effects that include anti-inflammatory, anti-pathogenic, antioxidant activity, and immunoregulatory influences. We tested the influence of 1000 mg quercetin (Q) with or without 120 mg epigallocatechin 3-gallate (EGCG), 400 mg isoquercetin, and 400 mg EPA-DHA (Q-EGCG) on changes in measures of immunity and inflammation before and after a 3-day period of heavy exertion. 39 trained cyclists were randomized to placebo, Q, or Q-EGCG, and ingested supplements in a double blinded fashion for 2 weeks prior to, during, and 1 week after a 3-d period in which subjects cycled for 3 h/d at 57% Wattsmax. Blood and saliva samples were collected before and after 2 weeks supplementation, immediately following the exercise bout on the 3rd day and 14-h post-exercise. Two weeks supplementation resulted in a significant increase in granulocyte oxidative burst activity (GOBA) in Q-EGCG relative to P and increases in plasma quercetin for Q and Q-EGCG. Immediately after the 3rd exercise bout, significant decreases for C-reactive protein, plasma IL-6 and IL-10 were measured in Q-EGCG compared to P. Granulocyte colony stimulating factor (GCSF) and CRP were reduced in Q-EGCG 14-h post-exercise. Two weeks supplementation with Q-EGCG was effective in augmenting GOBA, and countering inflammation following 3 days of heavy exertion in trained cyclists. Grant support from Quercegen Pharma." @default.
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- W100774288 date "2009-04-01" @default.
- W100774288 modified "2023-09-24" @default.
- W100774288 title "Influence of supplemental quercetin and epigallocatechin 3‐gallate on immunity and inflammation" @default.
- W100774288 doi "https://doi.org/10.1096/fasebj.23.1_supplement.907.6" @default.
- W100774288 hasPublicationYear "2009" @default.
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