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• W1007772811 endingPage "e0134361" @default.
• W1007772811 startingPage "e0134361" @default.
• W1007772811 abstract "The aim of the current study was to localize the epileptic focus and characterize its causal relation with other brain regions, to understand the cognitive deficits in children with benign childhood epilepsy with centrotemporal spikes (BECTS). Resting-state functional magnetic resonance imaging (fMRI) was performed in 37 children with BECTS and 25 children matched for age, sex and educational achievement. We identified the potential epileptogenic zone (EZ) by comparing the amplitude of low frequency fluctuation (ALFF) of spontaneous blood oxygenation level dependent fMRI signals between the groups. Granger causality analysis was applied to explore the causal effect between EZ and the whole brain. Compared with controls, children with BECTS had significantly increased ALFF in the right postcentral gyrus and bilateral calcarine, and decreased ALFF in the left anterior cingulate cortex, bilateral putaman/caudate, and left cerebellum. ALFF values in the putaman/caudate were positively correlated with verbal IQ scores in patients. The ALFF values in cerebellum and performance IQ scores were negatively correlated in patients. These results suggest that ALFF disturbances in the putaman/caudate and cerebellum play an important role in BECTS cognitive dysfunction. Compared with controls, the patients showed increased driving effect from the EZ to the right medial frontal cortex and posterior cingulate cortex and decreased causal effects from the EZ to left inferior frontal gyrus. The causal effect of the left inferior frontal gyrus negatively correlated with disease duration, which suggests a relation between the epileptiform activity and language impairment. All together, these findings provide additional insight into the neurophysiological mechanisms of epilepitogenisis and cognitive dysfunction associated with BECTS." @default.
• W1007772811 created "2016-06-24" @default.
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• W1007772811 date "2015-07-30" @default.
• W1007772811 modified "2023-10-15" @default.
• W1007772811 title "Local Activity and Causal Connectivity in Children with Benign Epilepsy with Centrotemporal Spikes" @default.
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• W1007772811 doi "https://doi.org/10.1371/journal.pone.0134361" @default.
• W1007772811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4520539" @default.
• W1007772811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26225427" @default.
• W1007772811 hasPublicationYear "2015" @default.
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