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- W1007995775 abstract "It is well recognized that metabolic control is complex: it involves the regulation at the gene expression level as well as the enzyme kinetic level. Extensive investigation over the past few decades has unveiled several mechanisms for regulation at the transcriptional and translationl levels, which regulate the amount of enzymes in the cell with time scales typically longer than 10 minutes. Regulation of enzyme activity at the kinetic level can occur at time scales less than a minute by ligand-binding (competitive or non-competitive)and protein modification such as phosphorylation, adenylylation, and urydylylation. In higher animals, these mechanisms are also complicated by the involvement of hormones, membrane potential, and secondary messengers. In some cases, the metabolic pathways are fully integrated with signal transduction pathways, and with gene expression at a longer time scale. Despite encouraging progress, signal transduction and gene expression in higher organisms are still poorly understood. Even in well studied microorganisms such as Escherichia coli and Saccharomyces cerevisiae, many unknowns still exist in the seemingly straightforward central metabolism1. One striking lesson was the 1980 discovery of 2,6-fructose bisphosphate2, the most important effector for phosphofructokinase and fructose 1,6-bisphosphatase in many eucaryotic organisms. Therefore, it is possible that new metabolites or new roles of known metabolites will be found in the future. However, this does not invalidate the value of theoretical analysis and mathematical modelling. Rather, it calls for more rigorous statement of assumptions and careful interpretation of results.KeywordsGlutamine SynthetaseMetabolite ConcentrationTransient ConcentrationResponse CoefficientControl CoefficientThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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- W1007995775 title "Metabolic Control Analysis Using Transient State Data" @default.
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