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- W1008078527 abstract "Objective To investigate correlation between thymidylate synthase enhancer region(TSER) polymorphism and the antitumor activities of 5-fluorouracil(5-Fu) determined by ATP sensitivity assay in vitro.Methods The carcinoma cells isolated from fresh gastric tissue in 45 patients were cultured in vitro.The sensitivity of these cells to 5-Fu were tested using ATP-TCA method.TSER genotypes were detected by PCR and the correlation between different of TSER genotypes and its chemosensitivity to 5-Fu was analyzed in this study.Results In all cases,the frequency distribution of TSER 2R/2R、2R/3R and 3R/3R genotypes were 6.7%(3/45)、31.1%(14/45) and 62.2%(28/45),respectively.The overall effective rate of 3R/3R group to 5-Fu was 33.3%(14/42).In 2R/2R and 2R/3R genotype group its effective rate to 5-Fu was 56.3%(9/16),which was significantly higher than that of 3R/3R genotype group(19.2%,P0.05).Conclusions The results in the present study suggest that the polymorphism of TSER was associated with the antitumor activities of 5-fluorouracil,indicating that analysis of TSER polymorphisms might be useful to direct 5-fluorourcil-based antitumor chemotherapy." @default.
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- W1008078527 date "2009-01-01" @default.
- W1008078527 modified "2023-09-27" @default.
- W1008078527 title "Correlation between TSER polymorphism and sensitivity of gastric cancer tissue to 5-fluorouracil." @default.
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