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• W1008095003 abstract "This chapter discusses developmental toxicity of engineered nanoparticles. Revolutionary developments of physics, chemistry and material sciences have led to the emergence of nanotechnology. Nano-objects have found different applications as diagnostic and therapeutic tools in biomedicine. Engineered nanoparticles are defined by differences in their shape, size, surface charge and chemical composition, mostly due to the mode of their production. Some of the nanoparticles are carbon nanoparticle, carbon nanotubes, quantum dots, inorganic nanoparticles and inorganic nanotubes. Non-degradable nanomaterials can accumulate in organs and inside cells where they can exert detrimental effects. One major uncertainty in interpretation of experimental toxicity studies as well as in risk assessment of engineered nanomaterial arises from lack of systematic knowledge about the physico-chemical characteristics of the material arriving at the major portals through which nanoparticles can enter the body, i.e. lung, skin, gastro-intestinal tract, nasal olfactory structures and eyes. The small size of nanoparticles allows them to easily enter and traverse tissues, cells and organelles since the actual size of engineered nanoparticles is similar to that of many biological molecules and structures. Nanoparticles are translocated from lung to blood and across the blood–brain barrier as well as the placenta. Maternal exposure to engineered nanoparticles may potentially affect fetal development directly as well as through indirect pathways. Engineered nanomaterials can cause inflammation, allergy, genotoxicity and carcinogenicity. The need for risk assessment of engineered nanomaterials has also generated a need for a novel risk assessment concept. The goal of control banding is to prevent excessive exposure to compounds such as engineered nanomaterials." @default.
• W1008095003 created "2016-06-24" @default.
• W1008095003 creator A5003243714 @default.
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• W1008095003 creator A5051278116 @default.
• W1008095003 date "2011-01-01" @default.
• W1008095003 modified "2023-10-17" @default.
• W1008095003 title "Developmental toxicity of engineered nanoparticles" @default.
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