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- W1008357070 abstract "A sejtkapcsolatok a daganatokban megvaltoznak, kulonosen a tight junction (TJ) gerincet alkoto claudin (CLDN) feherje csalad komponensei, melynek 24 tipusa ismert emberben. Tobb daganatban elsőkent vizsgalatuk a CLDN expresszio eltereseit protein es mRNS szinten. Megallapitottuk, hogy az egyes CLDN-ok expresszioja jelentősen nő a nyelőcső rakban, a Barrett oesophagusban es adenocarcinomaban (ACC). A CLDN mintazat elkuloniti a hepatoblastoma es endometrialis carcinoma formait, a pancreas endocrin tumorait es a ductalis ACC-t, valamint a tudőtumorokat, a primer es metasztatikus majdaganatokat. Egyes extracellularis matrix (ECM) komponensek, igy az agrin, valamint a matrilin2 expresszioja es lokalizacioja megvaltozik a cirrhosisban es majrakokban. Fenti vizsgalatok jelentősege, hogy szamos daganatban feltarta a sejtkapcsolatok es ECM valtozasait es igazolta, hogy az elteresek jellemzők az egyes tumorokra, kovetik a kiindulasi szovet sejtkapcsolo strukturainak feherje osszetetelet, bar expressziojuk merteke valtozik. A vizsgalt daganatok CLDN mintazata diagnosztikus ertekű. A vizsgalatok igazoltak, hogy a TJ dinamikusan valtozo protein osszetetele a carcinogenesis soran bonyolult funkcionalis valtozast takar es az egyes osszetevők aranya es egymassal valo kapcsolata a dontő az intakt sejtkapcsolat kialakulasaban. | Cell junctions change in tumors, especially the components of the claudin (CLDN) protein family (24 types of which are known in humans) forming the backbone of tight junctions (TJ). We were first to study CLDN expression alterations in several tumors at protein and mRNA levels. Our studies confirmed that expression of certain CLDNs shows significant increase in oesophageal squamous cell carcinoma, Barrett?s oesophagus and adenocarcinoma (ACC). The CLDN pattern differentiates components of hepatoblastomas and 2 types of endometrial carcinomas, endocrine tumors of the pancreas, ductal ACCs, lung tumors, primary and metastatic liver tumors. Certain extracellular matrix (ECM) components, as agrin, matrilin-2 exhibited altered expression and location in cirrhosis and liver cancers. Our observations revealed TJ and ECM changes in several tumor types, confirming that the changes are characteristic to the tumor. The CLDN pattern of the studied tumors are of diagnostic significance. Our studies confirmed that the dynamically changing protein composition of TJs covers complex functional changes during carcinogenesis, and the proportion and interrelationship of various components are decisive in the development of intact TJs." @default.
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- W1008357070 date "2009-01-01" @default.
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- W1008357070 title "Sejtadhéziós molekulák szerepe a daganatok, kiemelten a májrákok patogenezisében = The role of cell adhesion molecules in the pathogenesis of tumors, with emphasis on liver cancers" @default.
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