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• W1009689743 startingPage "1828" @default.
• W1009689743 abstract "Voriconazole is an azole useful for the prophylaxis and the treatment of aspergillosis and other fungal infections in immunosuppressed subjects, as those found in aplasia after aggressive polychemotherapy treatments, after hematopoietic stem cell, liver or lung transplantation. Its administration in therapeutic doses lead to extremely varied serum levels from patient to patient and even to the same patient. The explanations are varied: nonlinear pharmacokinetics, certain patient-related factors, including genetic polymorphisms in the cytochrome P450 2C19 gene, the kidney and liver function, simultaneous administration with other drugs metabolised by the same cytochrome. It is recommended to maintain the serum concentrations of voriconazole between 1.5 and 4 μg/mL. At lower values its efficacy decreases and at higher values the risk of neurological toxicity increases. Even at these concentrations it is not excluded the possible appearance of a variety of toxic effects, including on the liver, manifested by cholestasis, hepatocytolisis, or their combination. It is recommended to monitor the clinical and laboratory evolution of all patients treated with voriconazole, and of the serum levels of the drug of those who belong to risk groups, even if there is still no consensus on this issue, given the lack of correlation between the serum level and the occurrence of adverse effects in many patients." @default.
• W1009689743 created "2016-06-24" @default.
• W1009689743 creator A5046052621 @default.
• W1009689743 date "2015-01-01" @default.
• W1009689743 modified "2023-10-14" @default.
• W1009689743 title "Voriconazole and the liver" @default.
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• W1009689743 doi "https://doi.org/10.4254/wjh.v7.i14.1828" @default.
• W1009689743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4506940" @default.
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