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- W100983963 abstract "Recent studies have shown that ginger extract and curcumin work synergistically to promote wound healing in Temovate-treated rats. With this in mind, the current study focused on the effects of combined ginger and curcumin on organ cultured human skin and primary dermal fibroblasts. Dermal fibroblasts were treated for a 72-hour period with a range of ginger and curcumin concentrations, both individually and combined, in low calcium and high calcium media. Biopsy punches from the hip of adult human subjects were organ cultured for 6 days in supportive media and treated with a similar dose range of ginger and curcumin as the fibroblasts. Findings were parallel in fibroblast monolayer and organ cultured skin. The combination of ginger and curcumin protected fibroblasts from cytotoxicity under conditions in which survival did not occur in their absence. Taken together with the previous wound-healing study, these data support the synergistic action of ginger and curcumin and indicate their potential benefit in at-risk human skin. Work supported by NIH HL07097" @default.
- W100983963 created "2016-06-24" @default.
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- W100983963 date "2009-04-01" @default.
- W100983963 modified "2023-09-27" @default.
- W100983963 title "MMP‐1 Reduced in Organ Cultured Human Skin and Dermal Fibroblasts by Ginger and Curcumin" @default.
- W100983963 doi "https://doi.org/10.1096/fasebj.23.1_supplement.469.4" @default.
- W100983963 hasPublicationYear "2009" @default.
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