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- W1009845172 abstract "Border disease (BD) is a congenital disorder of lambs characterized in its typical form by poor viability, low birth weight, tremor, and in smooth-coated breeds by an unusually coarse, hairy, birth-coat. The typical form of BD virus infection, which results in the hairy-shaker lamb, may be regarded as a tolerant condition as the individual is persistently infected but does not produce either a humoral or a cellular immune response. In the alternative form of pathology (AP), which results in gross intracranial malformations, this tolerant state either does not develop or is broken at an early stage, the fetus responding with a necrotizing and mononuclear cell inflammatory reaction in the granuloprival layers of the developing central nervous system (CNS). Antiviral antibody is produced and infection appears to be eliminated before birth. Prominent among the factors that give rise to this altered response is the involvement of heterologous poor-fit antibody in the experimental system and it is clear that the virus is processed in some way, in vitro, or in the maternal host. Though the ovine placenta is impermeable to circulating maternal antibody, even when damaged in the typical form of BD, it is not unreasonable to speculate that virus, complexed with poor-fit antibody, might cross to the fetus, changing the usual pattern of infection and stimulating a response in the fetal host." @default.
- W1009845172 created "2016-06-24" @default.
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- W1009845172 date "1983-01-01" @default.
- W1009845172 modified "2023-09-24" @default.
- W1009845172 title "Some Interactions of Virus and Maternal/Foetal Immune Mechanisms in Border Disease of Sheep" @default.
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- W1009845172 doi "https://doi.org/10.1016/s0079-6123(08)63870-4" @default.
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