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- W1009998186 abstract "Nurohypophysial hormones are involved in the learning and memory processes, and several approaches have been used to determine the physiological significance of the neurohypophysial hormones in the memory processes. This chapter describes the various approaches that have been used to determine the physiological significance of the neurohypophysial hormones in the memory processes. Different approaches include animals with a vasopressin deficiency as induced by the removal of the neurointermediate lobe of the pituitary, rats of the Brattleboro strain that have a genetic disturbance in the synthesis of vasopressin, and rats with a temporary deficit in brain vasopressin produced by i.c.v. injection of specific vasopressin antiserum. Vasopressin facilitates memory consolidation and retrieval, while oxytocin may be regarded as an amnesic neuropeptide. The central nervous system (CNS) effects of these hormones are of central origin, as appeared from lesion studies, experiments in diabetes insipidus rats, studies from i.c.v. administered peptides and specific antisera particularly the brain areas, and studies on the vasopressin levels in blood and cerebrospinal fluid (CSF) during memory consolidation and retrieval. Neurochemical experiments suggest that the memory effects of the neurohypophysial hormones are mediated by modulation of catecholamine transmission in restricted areas in the brain. The neurohypophysial hormones have a variety of CNS effects—they modulate drug-seeking behavior, electrical self-stimulation, and tolerance development to and physical dependence on opiates. Other effects of vasopressin include temperature regulation, cardiovascular control, and brain development." @default.
- W1009998186 created "2016-06-24" @default.
- W1009998186 creator A5085824009 @default.
- W1009998186 date "1983-01-01" @default.
- W1009998186 modified "2023-10-14" @default.
- W1009998186 title "Central Actions of Neurohypophysial Hormones" @default.
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- W1009998186 doi "https://doi.org/10.1016/s0079-6123(08)64383-6" @default.
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