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- W101057007 abstract "Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of the leptin and insulin signaling pathways. The important roles of PTP1B related to obesity and diabetes were confirmed by a deletion of PTP1B gene in mice. Mice with the whole body deletion of PTP1B were protected against the development of obesity and diabetes. When PTP1B gene was deleted selectively in the brain of mice, the major effects on weight and glucose control were consistent with the whole body deletion of PTP1B. This is in contrast to the muscle-, liver-, and adipocyte-specific deletion, which had no beneficial effects on obesity. While these results indicate the importance of neuronal PTP1B in maintaining energy homeostasis, the peripheral PTP1B is also being investigated for their potential roles in the control of energy balance. Validation of PTP1B as a therapeutic target for obesity and diabetes prompted efforts to develop potent and selective inhibitors of PTP1B. Among the small molecule inhibitors investigated, trodusquemine, which acts both centrally and peripherally, is currently in phase 2 clinical trials. An approach using PTP1B-directed antisense oligonucleotides is also in phase 2 clinical trials." @default.
- W101057007 created "2016-06-24" @default.
- W101057007 creator A5062100767 @default.
- W101057007 date "2013-01-01" @default.
- W101057007 modified "2023-10-14" @default.
- W101057007 title "Protein Tyrosine Phosphatase 1B (PTP1B) and Obesity" @default.
- W101057007 cites W1497274503 @default.
- W101057007 cites W1540114282 @default.
- W101057007 cites W1653273172 @default.
- W101057007 cites W1963529746 @default.
- W101057007 cites W1965322940 @default.
- W101057007 cites W1965858496 @default.
- W101057007 cites W1970219648 @default.
- W101057007 cites W1971679833 @default.
- W101057007 cites W1977704860 @default.
- W101057007 cites W1983082230 @default.
- W101057007 cites W1989307463 @default.
- W101057007 cites W1991401793 @default.
- W101057007 cites W1992206443 @default.
- W101057007 cites W1993145131 @default.
- W101057007 cites W1995944520 @default.
- W101057007 cites W1996484759 @default.
- W101057007 cites W1996713062 @default.
- W101057007 cites W1996964761 @default.
- W101057007 cites W1998288762 @default.
- W101057007 cites W2009172922 @default.
- W101057007 cites W2009676330 @default.
- W101057007 cites W2010366787 @default.
- W101057007 cites W2012514869 @default.
- W101057007 cites W2013828738 @default.
- W101057007 cites W2019619651 @default.
- W101057007 cites W2020909072 @default.
- W101057007 cites W2022392858 @default.
- W101057007 cites W2024802365 @default.
- W101057007 cites W2025846514 @default.
- W101057007 cites W2026671374 @default.
- W101057007 cites W2029999922 @default.
- W101057007 cites W2031637294 @default.
- W101057007 cites W2033220684 @default.
- W101057007 cites W2039379511 @default.
- W101057007 cites W2042491249 @default.
- W101057007 cites W2043617798 @default.
- W101057007 cites W2050418518 @default.
- W101057007 cites W2052902385 @default.
- W101057007 cites W2052959593 @default.
- W101057007 cites W2053252199 @default.
- W101057007 cites W2053544216 @default.
- W101057007 cites W2054575721 @default.
- W101057007 cites W2058157372 @default.
- W101057007 cites W2060691137 @default.
- W101057007 cites W2062570379 @default.
- W101057007 cites W2064119981 @default.
- W101057007 cites W2064298888 @default.
- W101057007 cites W2067152194 @default.
- W101057007 cites W2067657272 @default.
- W101057007 cites W2069526456 @default.
- W101057007 cites W2071698219 @default.
- W101057007 cites W2074303577 @default.
- W101057007 cites W2078339510 @default.
- W101057007 cites W2079503496 @default.
- W101057007 cites W2081973667 @default.
- W101057007 cites W2086091436 @default.
- W101057007 cites W2087482176 @default.
- W101057007 cites W2091286894 @default.
- W101057007 cites W2091988898 @default.
- W101057007 cites W2094193605 @default.
- W101057007 cites W2096679957 @default.
- W101057007 cites W2098457930 @default.
- W101057007 cites W2098854471 @default.
- W101057007 cites W2101279411 @default.
- W101057007 cites W2109470426 @default.
- W101057007 cites W2110769037 @default.
- W101057007 cites W2115681043 @default.
- W101057007 cites W2118743996 @default.
- W101057007 cites W2123229219 @default.
- W101057007 cites W2123479382 @default.
- W101057007 cites W2128445664 @default.
- W101057007 cites W2129285977 @default.
- W101057007 cites W2140691623 @default.
- W101057007 cites W2141911861 @default.
- W101057007 cites W2143578581 @default.
- W101057007 cites W2145501578 @default.
- W101057007 cites W2145869245 @default.
- W101057007 cites W2148457238 @default.
- W101057007 cites W2149201695 @default.
- W101057007 cites W2149760830 @default.
- W101057007 cites W2158169974 @default.
- W101057007 cites W2159708653 @default.
- W101057007 cites W2166199238 @default.
- W101057007 cites W2169585787 @default.
- W101057007 cites W2334337188 @default.
- W101057007 doi "https://doi.org/10.1016/b978-0-12-407766-9.00017-1" @default.
- W101057007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23374726" @default.
- W101057007 hasPublicationYear "2013" @default.
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