Matches in SemOpenAlex for { <https://semopenalex.org/work/W1010867140> ?p ?o ?g. }
- W1010867140 endingPage "108" @default.
- W1010867140 startingPage "59" @default.
- W1010867140 abstract "This chapter discusses Vitamin K and γ-Carboxyglutamate Biosynthesis. Long periods of time may elapse between the discovery of a given vitamin deficiency disease, the isolation and structural analysis of the vitamin, and the final elucidation of its metabolic function. It is now established that vitamin K is part of a membrane bound carboxylase system and participates in the posttranslational carboxylation of selected peptide-bound glutamate residues in a number of vitamin K-dependent proteins. The requirements of this carboxylase system are reduced vitamin K, carbon dioxide, oxygen, and a suitable peptide substrate. The precise mechanism of the carboxylase reaction and the biochemical role of vitamin K are still unknown. It is now clear that vitamin K is also involved in an electron transport system in microsomes of mammalian organisms carrying out peptide-bound glutamate carboxylation. The chain involves NADH, vitamin K, and presumably oxygen as a terminal electron acceptor. The energy generated in this electron transport system is coupled in an as yet undetermined way to CO2 fixation in glutamate. The intuitive belief that vitamin K should be involved in an electron transport system in expressing its procoagulant activity has been vindicated by recent work." @default.
- W1010867140 created "2016-06-24" @default.
- W1010867140 creator A5010696946 @default.
- W1010867140 creator A5035683465 @default.
- W1010867140 date "1978-01-01" @default.
- W1010867140 modified "2023-09-23" @default.
- W1010867140 title "Vitamin K and γ-Carboxyglutamate Biosynthesis" @default.
- W1010867140 cites W1026251619 @default.
- W1010867140 cites W105909189 @default.
- W1010867140 cites W117602840 @default.
- W1010867140 cites W1246994546 @default.
- W1010867140 cites W1452653100 @default.
- W1010867140 cites W146793268 @default.
- W1010867140 cites W1480423379 @default.
- W1010867140 cites W1480653126 @default.
- W1010867140 cites W1480740682 @default.
- W1010867140 cites W1483640756 @default.
- W1010867140 cites W1486755746 @default.
- W1010867140 cites W1492322138 @default.
- W1010867140 cites W1498794674 @default.
- W1010867140 cites W1501712515 @default.
- W1010867140 cites W1509745955 @default.
- W1010867140 cites W1518690772 @default.
- W1010867140 cites W1523245548 @default.
- W1010867140 cites W1543394411 @default.
- W1010867140 cites W1552768178 @default.
- W1010867140 cites W1555710117 @default.
- W1010867140 cites W1558731734 @default.
- W1010867140 cites W1559899200 @default.
- W1010867140 cites W1563120401 @default.
- W1010867140 cites W1563616948 @default.
- W1010867140 cites W1573305046 @default.
- W1010867140 cites W1578595543 @default.
- W1010867140 cites W1584590512 @default.
- W1010867140 cites W1594373951 @default.
- W1010867140 cites W1604234143 @default.
- W1010867140 cites W1606986099 @default.
- W1010867140 cites W1608567816 @default.
- W1010867140 cites W1623126220 @default.
- W1010867140 cites W1659341972 @default.
- W1010867140 cites W172982423 @default.
- W1010867140 cites W1773173982 @default.
- W1010867140 cites W1782728159 @default.
- W1010867140 cites W1791599099 @default.
- W1010867140 cites W1833029693 @default.
- W1010867140 cites W185351899 @default.
- W1010867140 cites W1866896121 @default.
- W1010867140 cites W1867288595 @default.
- W1010867140 cites W1938510020 @default.
- W1010867140 cites W1947232287 @default.
- W1010867140 cites W1963953060 @default.
- W1010867140 cites W1965293723 @default.
- W1010867140 cites W1966283250 @default.
- W1010867140 cites W1966296019 @default.
- W1010867140 cites W1966720341 @default.
- W1010867140 cites W1968544024 @default.
- W1010867140 cites W1969197911 @default.
- W1010867140 cites W1969497645 @default.
- W1010867140 cites W1970875864 @default.
- W1010867140 cites W1971982310 @default.
- W1010867140 cites W1972750083 @default.
- W1010867140 cites W1974508345 @default.
- W1010867140 cites W1975002306 @default.
- W1010867140 cites W1975923363 @default.
- W1010867140 cites W1976050853 @default.
- W1010867140 cites W1976863031 @default.
- W1010867140 cites W1977523693 @default.
- W1010867140 cites W1978708139 @default.
- W1010867140 cites W1979175205 @default.
- W1010867140 cites W1980600234 @default.
- W1010867140 cites W1980753707 @default.
- W1010867140 cites W1982746604 @default.
- W1010867140 cites W1983637730 @default.
- W1010867140 cites W1984500290 @default.
- W1010867140 cites W1984569581 @default.
- W1010867140 cites W1985411214 @default.
- W1010867140 cites W1986372056 @default.
- W1010867140 cites W1988040355 @default.
- W1010867140 cites W1989040451 @default.
- W1010867140 cites W1989496602 @default.
- W1010867140 cites W1994142322 @default.
- W1010867140 cites W1995813025 @default.
- W1010867140 cites W1996439365 @default.
- W1010867140 cites W1996760188 @default.
- W1010867140 cites W1997354280 @default.
- W1010867140 cites W1998800340 @default.
- W1010867140 cites W2000735792 @default.
- W1010867140 cites W2000892748 @default.
- W1010867140 cites W2001696140 @default.
- W1010867140 cites W2002798973 @default.
- W1010867140 cites W2004089633 @default.
- W1010867140 cites W2005224635 @default.
- W1010867140 cites W2005908510 @default.
- W1010867140 cites W2006704924 @default.
- W1010867140 cites W2006764976 @default.
- W1010867140 cites W2009655260 @default.
- W1010867140 cites W2009830481 @default.
- W1010867140 cites W2010539561 @default.