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- W1011527639 abstract "DNA methylation plays an important role in the regulation of gene expression. Tumor cells are characterized by alterations of DNA methylation pattern, namely local CpG island hypermethylation and genome wide hypomethylation. The hypomethylation of the genome affects many repetitive sequences and transposable elements and is believed to results in chromosomal instability and increased mutations events. In this review we summarize the current knowledge concerning epigenetic mechanisms related to cancer, especially the relationship of DNA hypomethylation to carcinogenesis. numer.indb 21 2010-03-08 22:37:44" @default.
- W1011527639 created "2016-06-24" @default.
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- W1011527639 date "2010-01-01" @default.
- W1011527639 modified "2023-10-18" @default.
- W1011527639 title "Globalna hipometylacja DNA – znaczenie w procesie kancerogenezy" @default.
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