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- W1012355910 abstract "MAPK/Erk kinase (Mek) is a dual-specificity PK responsible for phosphorylation of MAP kinase (Erk1/2) on threonine and tyrosine residues. These phosphorylation events dramatically increase the capacity of MAP kinase to phosphorylate exogenous substrates, such as microtubule-associated proteins and myelin basic protein. The MAP kinases encoded by the ERK1/ERK2 genes are the only substrates of Mek thus far reported. Two related gene products, Mek1 and Mek2, have been reported in the mouse. Both are apparently monomers. Outside vertebrates, Mek1 is most closely related in size and sequence to Schizosaccharomyce pombe Byr1. They are 45% identical in amino acid sequence, although Byr1 has no insert in the kinase domain. Mek1/Mek2 is also related to Pbs2 and Ste7 from Saccharomyces cerevisiae. Mek can be assayed using a glutathione-S-transferase/Erk fusion protein. Mek is regulated by reversible protein phosphorylation on serine or threonine by one or more Mek kinases (MAP kinase kinase kinases), including Raf-1. Mek mRNA is widely expressed in many adult rat or mouse tissues." @default.
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- W1012355910 date "1995-01-01" @default.
- W1012355910 modified "2023-09-25" @default.
- W1012355910 title "Mek" @default.
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- W1012355910 doi "https://doi.org/10.1016/b978-012324719-3/50085-6" @default.
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