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- W101272451 abstract "Bipolar disorder and major depression are common debilitating mood disorders. The latest World Health Organization's World Mental Health Survey Initiative estimated the median and inter-quartile lifetime prevalence for mood disorders to be 3.3 –21.4% (Kessler et al. 2007). In Global Burden of Disease surveys, depression has been estimated to be a leading cause of disability worldwide and is projected to be a major cause of morbidity in 2030 (first in high income countries, second in medium income countries and third in low income countries) (Mathers and Loncar 2006). A recent study has reported that the rise of high levels of psychological stress in the workplace seems to precipitate depression and generalized anxiety disorders (Melchior et al. 2007). Taken together, these suggest that mood disorders impose an enormous burden on families, society and the health care system. Reducing this burden may require improved diagnostic precision and treatment modalities, preventive measures and greater public awareness. A key element in achieving this goal involves the discovery of genetic and environmental factors that contribute to disease risk. So far, from a combination of approaches evidence for risk-conferring variation in various genes has emerged although further confirmation is needed and functional relevance has to be established. This chapter will focus on strategies designed to clarify the genetics and underlying mechanisms of mood disorders, and discuss progress in this endeavor and the challenge that remains." @default.
- W101272451 created "2016-06-24" @default.
- W101272451 creator A5041991034 @default.
- W101272451 creator A5061632695 @default.
- W101272451 date "2008-11-27" @default.
- W101272451 modified "2023-09-23" @default.
- W101272451 title "Decoding the Genetics and Underlying Mechanisms of Mood Disorders Sevilla D. Detera-Wadleigh and Takeo Yoshikawa" @default.
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