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• W1013045579 abstract "This chapter reviews the procedures developed for the isolation of in vitro systems from cancer cells and the characteristics and preparations of these systems. The results obtained from the systems of cancer cells are compared and contrasted with the results obtained from systems from microbial cells and animal tissues. One of the initial studies of the incorporation of labeled amino acids by an in vitro system of tumor origin has been reported in 1957. In this study, the Ehrlich mouse ascites tumor was utilized for preparing pH 5-insoluble and microsornal fractions. Deoxycholate-insoluble particles and a NaCl-insoluble fraction were obtained from the crude microsoinal pellets. The deoxycholate-insoluble particles showed three major peaks. The incorporation of C13-amino acids into proteins was determined by the addition of glucose, buffer, and labeled amino acid to the whole ascites fluid. The findings from the study were found to be consistent with the concept that most of the amino acids incorporated into whole cell proteins pass through the ribonucleoproteins. Another investigation to compare the mechanism of protein synthesis of tumor cells with that of other mammalian cells was reported in 1964. Strain DNA X Swiss hybrid mice were inoculated intraperitonially with L-1210 mouse ascites leukemia cells. An active amino acid-incorporating system was developed utilizing the Novikoff rat ascites tumor. This hepatoma, initially induced by the administration of diets containing carcinogenic azo dyes, possesses many advantages for the investigation of in vitro protein biosynthesis. From the studies reviewed in this chapter, it may be assumed that same general mechanism for amino acid activation, aminoacyl transfer, and amino acid polymerization is operative in mammalian cells, and that malignant cells do not differ radically in this respect." @default.
• W1013045579 created "2016-06-24" @default.
• W1013045579 creator A5006600520 @default.
• W1013045579 date "1967-01-01" @default.
• W1013045579 modified "2023-09-26" @default.
• W1013045579 title "In Vitro Studies on Protein Synthesis by Malignant Cells" @default.
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• W1013045579 doi "https://doi.org/10.1016/s0065-230x(08)60077-9" @default.
• W1013045579 hasPublicationYear "1967" @default.
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