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- W1013410924 abstract "Publisher Summary This chapter discusses use of biological markers in the quantitative assessment of neurotoxic risk. Use of biomarkers offers a number of advantages. It can lead to a more complete scientific understanding, incorporating more relevant information about causal mechanisms, than a simple input-output analysis based on external dose and the incidence of end effects. It offers the eventual prospect of a better mechanism-based projection of risk beyond the range of possible direct observations in terms of dose rate, duration, and species. It offers the possibility of greater sensitivity of detection and quantification of adverse effects in some cases, going from the whole organism to the cellular or subcellular level for the units in which damage is quantified and analyzed. Moreover, physical or physiological biomarkers offer the prospect of confirming exposure-related effects and narrowing the search for causative agents in cases where effects are detected in the form of long-term changes in higher nervous system functions that may be subject to a number of psychosocial confounding influences, which are difficult to control for some exposed groups. This chapter discusses how biomarkers can be used in both basic scientific research and risk assessment. Analyzing dose-time-response relationships for classic chronic toxic effects using the case of acrylamide is also discussed in this chapter." @default.
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- W1013410924 date "1995-01-01" @default.
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- W1013410924 title "Use of Biological Markers in the Quantitative Assessment of Neurotoxic Risk" @default.
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