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• W1013553640 abstract "A large body of studies has investigated the potential role of ABCB1 polymorphism in ALL susceptibility. However, the results are conflicting. The aim of the present meta-analysis was to define the effect of ABCB1 polymorphism on ALL risk.We identified 8 eligible studies involving 1,308 cases and 1,427 controls through searching PubMed and Enbase databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to access the strength of the association with both fixed effects and random effect models.We found ABCB1 polymorphism was associated with an increased risk of ALL under the homozygote genotypes (TT vs. CC: OR, 1.29, 95% CI, 1.08-1.54), the recessive model (TT vs. CT + CC: OR, 1.47, 95% CI, 1.02-2.13) and the allele model (T vs. C: OR, 1.14, 95% CI, 1.04-1.25). Similar results were indicated in Asian populations (TT vs. CC: OR, 1.79, 95% CI, 1.32-2.43; TT vs. CT + CC: OR, 2.55, 95% CI, 1.47-4.43; T vs. C: OR, 1.38, 95% CI, 1.18-1.62), but not in Caucasian populations.These findings indicate that ABCB1 polymorphism may play a critical role in the development of ALL in Asians." @default.
• W1013553640 created "2016-06-24" @default.
• W1013553640 creator A5005011787 @default.
• W1013553640 creator A5045839676 @default.
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• W1013553640 date "2015-01-01" @default.
• W1013553640 modified "2023-09-23" @default.
• W1013553640 title "ABCB1 polymorphism and susceptibility to acute lymphoblastic leukemia: a meta analysis." @default.
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• W1013553640 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4509248" @default.
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