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- W1013654 abstract "Discreet regions in the heart, called ganglionic plexuses (GPs) are a network of integration centres that process afferent and efferent nerve activity to modulate the heart. We aimed to investigate the role of the right atrial GP (RAGP) in controlling heart rate (HR). Methods The decentralised innervated Langendorff perfused rabbit heart model was used (n=6). 1) RAGP was stimulated using 0.1–0.4mg nicotine (0.1ml) in 2) the presence of 0.1μm Atropine (At) or 1.8μm Metoprolol (Met), 3) The right vagus nerve was stimulated (VNS, 7H10V) before and after RAGP stimulation and 4) VNS before and following coronary artery occlusion. Data are mean±SEM, repeated measures ANOVA or Students t-test. Results i) RAGP stimulation elicited an initial bradycardia (145±9 to 109±3bpm, P<0.05) and secondary tachycardia (226±12bpm, P<0.001, n=5) ii) At abolished the bradycardia (139±8 to 138±10bpm, P=NS), but not the tachycardia (247±9bpm, P<0.001). Met did not affect the bradycardia (135±7 to 106±4, P<0.05) but abolished the tachycardia (128±6bpm, P=NS, N=5. iii) VNS-bradycardia was augmented after RAGP stimulation (−81±8 vs 142±9bpm, P<0.01, n=3). iv) Coronary artery occlusion increased VNS-bradycardia (−45±6 vs −68±8bpm, P<0.05, n-4). Conclusion This is the first data representing GP modification in the rabbit showing that RAGP activation elicits a mixed autonomic HR response, via vagal and sympathetic activation that enhanced VNS-bradycardia. In addition, novel data shows that acute ventricular ischemia augments the HR effect of cervical VNS confirming that the RAGP is important in controlling HR in this species. Research support from the University of Leicester" @default.
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- W1013654 date "2012-04-01" @default.
- W1013654 modified "2023-09-23" @default.
- W1013654 title "Modulation of Vagus Nerve Stimulation via Ganglionic Plexus activation and Ventricular Ischaemia" @default.
- W1013654 doi "https://doi.org/10.1096/fasebj.26.1_supplement.lb789" @default.
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