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- W1014373008 abstract "Publisher Summary This chapter discusses tumorigenicity testing and mass propagation. The hairless nude phenotype in the mouse results from an inherited developmental defect, which is determined by an autosomal recessive mutation that segregates according to the simple Mendelian laws. Immunological rejection of heterologous tissue grafts in an animal depends primarily on the T-cell-mediated immunity of the host; the nude mouse is unable to reject implanted cells or tissues from a genetically nonidentical donor. Heteroploid mammalian cell lines, most of which exhibit variable degrees of transformed phenotypes in vitro and are tumorigenic in nude mice, can be grown as large tumors in nude mice by injecting 108 or fewer cells. The parameter best correlated with tumor formation in vivo is the “anchorage-independent” phenotype, as measured by colony-forming efficiency in soft agar or methylcellulose." @default.
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- W1014373008 date "1979-01-01" @default.
- W1014373008 modified "2023-10-12" @default.
- W1014373008 title "[31] Use of nude mice for tumorigenicity testing and mass propagation" @default.
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- W1014373008 doi "https://doi.org/10.1016/s0076-6879(79)58152-x" @default.
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