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- W101523574 abstract "1772 Objectives: To assess the diagnostic utility of hybrid PET-CT with FDG in patients with known CLL Methods: We performed 11 PET-CT scans (Siemens Biograph) in 7 patients (3 male, 4 female, age range 50-70 years) with clinically confirmed CLL. CT transmission scans were obtained after administration of oral contrast material. Two patients underwent both pre- and post-treatment scans. Diagnostic validation was by a combination of clinical and radiographic follow-up for 6 months to 8 years. Maximum standardized uptake values (SUVmax)were obtained for all evident lesions. Results: All 7 patients had clinically proven CLL and 2 developed clinically evident Richter’s transformation. SUVmax in transformed disease ranged from 10 to 30 for the evident adenopathy, splenomegaly and osseous involvement. The SUVmax ranged for subcentimeter nodes were 1.7-3. SUVmax in the remaining 5 patients ranged from 1.3 to 2.1 for the evident adenopathy. CT identified adenopathy or splenomegaly in 4 patients while PET showed abnormal marrow activity in 2 patients, but normal activity in other CT abnormalities. In 2 patients with documented Richter’s transformation, PET alone detected 6/6 sites of presumed transformation with abnormal hypermetabolism while CT alone only detected 3/6 sites by either new or worsening adenopathy (FN: bone marrow and subcentimeter nodes). In the first patient with Richter’s transformation, both PET and CT demonstrated concordant partial response to CHOP chemotherapy and Rituxin with decreased adenopathy and hypermetabolism. In the second patient, PET showed mixed response to MINE chemotherapy and Rituxin with 40% reduction of osseous hypermetabolism, but stable hypermetabolism in the known extensive adenopathy, while CT showed no significant interval structural change. Both of these patients eventually had progression of the disease in the follow-up PET-CT scan 2-3 months later. Conclusions: PET and CT are complementary in defining the extent of disease in CLL. However, PET may have a role in identifying sites of Richter’s transformation and for assessing treatment response." @default.
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- W101523574 date "2006-05-01" @default.
- W101523574 modified "2023-09-26" @default.
- W101523574 title "FDG PET-CT in chronic lymphocytic leukemia" @default.
- W101523574 hasPublicationYear "2006" @default.
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