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- W1016155516 abstract "The 4-quinolinone moiety is a fundamental pharmacophore in potent antibacterial drugs [1]; interesting biological activity has also been observed for other 4-quinolinones with sulfur functional groups, for example 4-quinolinone-3-sulfonamides have antihypertensive activity [2] and 3-alkylsulfinyl-4-quinolinones act as vasodilatators [3,4]. The lipophilicity of drugs has an important effect on their biological activity [5] and the correlation between biological properties and lipophilicity has been examined for antibacterial 4-quinolinones [6] and also to evaluate the proconvulsant activity of 4-quinolinone drugs [7]. This paper describes RPTLC evaluation of" @default.
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- W1016155516 date "2003-01-01" @default.
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- W1016155516 title "Lipophilicity indexes of some 3-alkylthio and 3-alkylsulfinyl 4(1H)-quinolones" @default.
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