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- W101627249 abstract "Objective: To determine the impact of protein co-ingestion before and after exercise on S6K1 and S6 phosphorylation status in human muscle. Design: Before, immediately after and 1h after resistance exercise, subjects consumed 0.3 g·kg−1 carbohydrate with or without 0.15 g·kg−1 protein (CHO and CHO+PRO test, respectively). Muscle biopsies were taken before and immediately after exercise and after 1 and 4h of recovery to determine 4E-BP1, S6K1 (T389) and S6 phosphorylation status in skeletal muscle tissue. Results: Following resistance exercise, 4E-BP1 phosphorylation status was reduced to a greater extent in the CHO vs. CHO+PRO test (−48±7 vs. −15±14%, respectively; P<0.01). During recovery, 4E-BP1 phosphorylation status increased in both trials (P<0.01) and tended to be higher in the CHO+PRO test (P=0.08). In contrast to the CHO test, S6K1 phosphorylation at T389 was increased following exercise in the CHO+PRO test (−4±2 vs. +78±2%, respectively; P<0.01). During recovery, S6K1 phosphorylation remained higher in the CHO+PRO test (P<0.05). S6 phosphorylation was substantially higher following exercise (1.69±0.35 vs. 0.45±0.07, respectively; P<0.01) and remained higher during recovery in the CHO+PRO compared to the CHO test. Conclusions: The ingestion of protein before and after resistance exercise is essential to fully activate the translation initiation process." @default.
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- W101627249 date "2007-01-01" @default.
- W101627249 modified "2023-09-30" @default.
- W101627249 title "Protein intake is essential to increase S6K1 phosphorylation following exercise" @default.
- W101627249 doi "https://doi.org/10.1096/fasebj.21.6.a837-a" @default.
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