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- W1016523919 abstract "In vertebrate rod outer segments (ROSs), guanosine 3′,5′-cyclic monophosphate (cGMP) appears to be directly involved in the process of visual transduction. The illumination of rhodopsin leads to the activation of cGMP phosphodiesterase (PDE) through transducin. The resulting fall in cytoplasmic cGMP concentration contributes to closure of cGMP-sensitive cation channels, causing the hyperpolarization of plasma membranes. Moreover, recovery of the dark state requires the resynthesis of cGMP by guanylate cyclase. To explain the mechanisms for the recovery of the dark state, isolation and reconstitution of guanylate cyclase in detergent-free systems are essential. The chapter also describes the basic characterization of guanylate cyclase from amphibian and bovine ROS. Guanylate cyclase is analyzed by measuring the amount of [ 32 P]cGMP that is derived from [α- 32 P]GTP in the presence of [ 3 H]cGMP, 3-isobutyl-l-methylxanthine, and a GTP-generating system." @default.
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- W1016523919 date "1993-01-01" @default.
- W1016523919 modified "2023-09-27" @default.
- W1016523919 title "Preparation and Characterization of Guanylate Cyclase from Vertebrate Rod Photoreceptors" @default.
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- W1016523919 doi "https://doi.org/10.1016/b978-0-12-185279-5.50022-4" @default.
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