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- W1016638412 abstract "This chapter discusses the new antibacterial agents, antimicrobial agents, and various aspects of antimicrobial chemotherapy. The orally active third generation cephalosporin FK 027 (FR 17027) continued to be extensively studied in vitro and in vivo. Oral administration of cefuroxime axetil, the 1-acetoxyethyl ester prodrug of cefuroxime, to human volunteers produced higher peak serum levels than an equivalent dose of ampicillin and urinary recovery of 35%. Novel oxacephem derivative (6315-S,7), exhibited broad, potent anti-bacterial spectrum with the exception of activity against Pseudornonas. The effect on antibacterial activity of α-substituents in the 2-(2-amino-4-thiazolyl)acetyl side chain of ceftizoxime had been of great interest to the researchers working on anti-bacteraial agents. Reviews and symposiums on this topic project penicillin as orally effective prodrug, delivering good blood levels of temocillin after oral administration to human volunteer. The chapter discusses the role of carbupenems, β-lactarnuse inhibitors, aminoglycosides, and other associated compounds and antibacterial agents. Interest remained high in the synthesis of nalidixic acid analogs. Rosoxacin derivative win 35,349 showed good activity in vitro and in vivo against strains of Staphylococcus aureus and epidennidus. Because of the improved potency and spectrum, most efforts were centered on 6-fluoro analogs of pipemidic acid. Pefloxacin (1589 RB, 39) penetrated inflammatory cerebrospinal fluid at effective anti-bacterial levels after oral or parenteral administration in patients with bacterial meningitis." @default.
- W1016638412 created "2016-06-24" @default.
- W1016638412 creator A5053723666 @default.
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- W1016638412 date "1984-01-01" @default.
- W1016638412 modified "2023-09-23" @default.
- W1016638412 title "Chapter 11. Antibacterial Agents" @default.
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